World Health Organization

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Presentation transcript:

World Health Organization 25 August, 2018 Access to medicines: Antimalarials WHO / UNICEF TBS - Access to Medicines 19 November 2008, Geneva Silvia Schwarte Global Malaria Programme

World Health Organization Outline 25 August, 2018 WHO MTG – Policy – Procurement Funding Paediatric antimalarial medicine Quality Monotherapy ban

World Health Organization ACTs: policy adoption, deployment, past procurement and 2008/09 forecast World Health Organization 25 August, 2018 Forecast Millions of ACT treatment courses 6-24 months from adoption to deployment Cumulative number of countries

Increasing resources for ACTs World Health Organization Increasing resources for ACTs 25 August, 2018 Round 7 GFATM approved 62% of malaria grants, and Round 8 approved 68% of malaria grants UNITAID: new funding for AIDS, TB and malaria medicines Affordable Medicine Facility for malaria (AMFm) – GFATM approved initial roll-out plan for 11 countries to start in April 09 Successful applications to GFATM Round 6, 7 and 8 Millions USD

Children's medicines: specific requirements World Health Organization Children's medicines: specific requirements 25 August, 2018 Correct dosing: extrapolating information obtained with adults or fractioning of adult dosage may be inadequate => need for appropriate dose-finding studies Ease of administration: taste, colour, flavour – but cave: excipients - alcohol, sugar shall be avoided - grant stability while certain preservative cannot be used in children Choose suitable formulations: - Liquid: syrups, solutions, suspensions – stability, reconstitution - Semi-solid: suppositories – heat stability, pre-referral treatment (MTG 2006) - Solid: (easy breakable or dispersible) tablets, capsules, granules, pellets Affordable price despite higher development costs Supply Chain issues (volume, transport and storage costs, distribution)

World Health Organization 25 August, 2018 Co-blister Fixed-dose Co-bl.

World Health Organization 25 August, 2018 Manufacturers of oral artemisinin monotherapies 12/68 (18%) withdrew their products 22/68 (32%) intend to comply with WHO ban Number of companies Substandard medicines?

World Health Organization 25 August, 2018 Thank you