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© The Author(s) 2014. Published by Science and Education Publishing. Table 3. Conditions with increased IEL and/or villous atrophy and crypt hyperplasia that can mimic CD Helicobacter pylori infection ↑ IEL Drugs ↑ IEL (e.g. NSAIDs) + villous atrophy (e.g. olmesartan) Tropical sprue Villous atrophy + crypt hyperplasia Giardia lamblia infection ± villous atrophy Bacterial overgrowth, other infections (e.g. parasitic) ↑ IEL ± villous atrophy Prolonged viral gastroenteritis ↑ IEL + villous atrophy Other food allergies (e.g. cow's milk protein) Autoimmune enteropathy ↑ IEL + villous atrophy ± crypt hyperplasia Extraintestinal autoimmune disorders IgA deficiency and CVID Peptic duodenitis Crohn’s disease and ulcerative colitis ↑ IEL - increased number of intraepithelial lymphocytes ± - variable presence of changes. Marián Švajdler et al. Diagnosing Celiac Disease: Role of the Pathologists. International Journal of Celiac Disease, 2014, Vol. 2, No. 2, 70-75. doi:10.12691/ijcd-2-2-10 © The Author(s) 2014. Published by Science and Education Publishing.