Fig. 1 Top, Locomotor activity in male bGH transgenic mice (n = 10) and nontransgenic control mice (n = 25) at their first encounter with the locomotor.

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Presentation transcript:

Fig. 1 Top, Locomotor activity in male bGH transgenic mice (n = 10) and nontransgenic control mice (n = 25) at their first encounter with the locomotor activity boxes. Statistics were determined by two-factor repeated measures ANOVA: group effect, P = 0.0017; time effect, P < 0.0001; and interaction term, P < 0.0001. Bottom, Locomotor activity in bGH transgenic mice (n = 10) and nontransgenic control mice (n = 25) at their second encounter with the locomotor activity boxes. All animals received 0.9% NaCl, ip, 5 min before placement in the boxes. Statistics were determined by two-factor repeated measures ANOVA: group effect, P = 0.4048; time effect, P < 0.0001; and interaction term, P = 0.1684. Bovine Growth Hormone Transgenic Mice Display Alterations in Locomotor Activity and Brain Monoamine Neurochemistry1 Endocrinology. 1999;140(12):5619-5625. doi:10.1210/endo.140.12.7181 Endocrinology | Copyright © 1999 by The Endocrine Society

Fig. 2 Locomotor activity in bGH transgenic mice (n= 9) and nontransgenic control mice (n = 25) at their third encounter with the locomotor activity boxes. Left panel, All animals received 1 mg/kg d-amphetamine, ip, 5 min before placement in the boxes. Statistics were determined by two-factor repeated measures ANOVA: group effect, P = 0.0016; time effect, P < 0.0001; and interaction term, P = 0.0002. Right panel, The calculated difference between the locomotor activity induced by d-amphetamine week 3 and that induced by 0.9% NaCl week 2 in each animal and group. Statistics were determined by two-factor repeated measures ANOVA: group effect, P = 0.0407; time effect, P < 0.0001; and interaction term, P = 0.0018. Bovine Growth Hormone Transgenic Mice Display Alterations in Locomotor Activity and Brain Monoamine Neurochemistry1 Endocrinology. 1999;140(12):5619-5625. doi:10.1210/endo.140.12.7181 Endocrinology | Copyright © 1999 by The Endocrine Society

Fig. 3 Locomotor activity in bGH transgenic mice (n= 10) and nontransgenic control mice (n = 23) at their fourth encounter with the locomotor activity boxes. Left panel, All animals received 2.5 g/kg ethanol, ip, 5 min before placement in the boxes. Statistics were determined by two-factor repeated measures ANOVA: group effect, P = 0.0632; time effect, P < 0.0001; and interaction term, P = 0.1096. Right panel, The calculated difference between the locomotor activity induced by ethanol week 4 and that induced by 0.9% NaCl week 2 in each animal and group. Statistics were determined by two-factor repeated measures ANOVA: group effect, P = 0.1596; time effect, P = 0.0125; and interaction term, P = 0.4460. Bovine Growth Hormone Transgenic Mice Display Alterations in Locomotor Activity and Brain Monoamine Neurochemistry1 Endocrinology. 1999;140(12):5619-5625. doi:10.1210/endo.140.12.7181 Endocrinology | Copyright © 1999 by The Endocrine Society

Fig. 4 Tissue levels of monoamines and monoamine metabolites, and quotients between metabolites and monoamines, in bGH transgenic mice and nontransgenic control mice in seven different brain regions. Data are expressed as a percentage of the control value. Shown are the mean ± sem of n observations. Statistics were determined by Student’s t test: *, P < 0.05; **, P < 0.01; and*** , P < 0.001. Bovine Growth Hormone Transgenic Mice Display Alterations in Locomotor Activity and Brain Monoamine Neurochemistry1 Endocrinology. 1999;140(12):5619-5625. doi:10.1210/endo.140.12.7181 Endocrinology | Copyright © 1999 by The Endocrine Society