Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening Amina Kurtovic-Kozaric, Lejla.

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Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening Amina Kurtovic-Kozaric, Lejla Mehinovic, Radmila Malesevic, Semir Mesanovic, Tijana Jaros, Meliha Stomornjak-Vukadin, Mirela Mackic-Djurovic, Slavica Ibrulj, Ilvana Kurtovic-Basic, Mirza Kozaric European Journal of Obstetrics and Gynecology and Reproductive Biology Volume 206, Pages 79-83 (November 2016) DOI: 10.1016/j.ejogrb.2016.08.038 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Total numbers of T21 cases diagnosed prenatally and postnatally from 2005 to 2015. (A and B) Annual distribution of T21 cases diagnosed prenatally (gray bars) and postnatally (black bars) in Bosnia and Herzegovina. European Journal of Obstetrics and Gynecology and Reproductive Biology 2016 206, 79-83DOI: (10.1016/j.ejogrb.2016.08.038) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Total (gray) and LB prevalence (black) per 10,000 births of trisomy 21, in the period from 2005 to 2015. European Journal of Obstetrics and Gynecology and Reproductive Biology 2016 206, 79-83DOI: (10.1016/j.ejogrb.2016.08.038) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 T21 total and LB prevalence per 10,000 births for Bosnia and Herzegovina, Europe [7] and USA [8]. European Journal of Obstetrics and Gynecology and Reproductive Biology 2016 206, 79-83DOI: (10.1016/j.ejogrb.2016.08.038) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 The effect of maternal age on T21 distribution. (A) The distribution of T21 pregnancies by maternal age. (B) Prenatal prevalence per 10,000 births (log scale) of T21 by maternal age. European Journal of Obstetrics and Gynecology and Reproductive Biology 2016 206, 79-83DOI: (10.1016/j.ejogrb.2016.08.038) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Distribution of the most common indications for prenatal invasive testing. US—ultrasound screening; B—biochemical maternal serum screening; AMA—advanced maternal age. Other—family history, mother’s anxiety, and other reasons. European Journal of Obstetrics and Gynecology and Reproductive Biology 2016 206, 79-83DOI: (10.1016/j.ejogrb.2016.08.038) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions