Research Challenges and Experiences Esmita Charani NIHR Health Protection Research Unit in HCAI and AMR

Background MPharm 2002 – not all that exciting Trained at Cambridge University Hospitals MSc 2006 – pivotal No research experience Imperial 2009 – 3 year fixed term contract PhD Imperial 2017

Challenges Independent working Looking out for funding Rejection NHS – Academia interface Ethics Bureaucracy

Challenges Independent working Looking out for funding Rejection NHS – Academia interface Ethics Bureaucracy You are not re-inventing the wheel – someone has done it before you

Experiences Wealth of knowledge Gaining expertise Exposure to leaders in the field Travel Networking Influencing decision making What motivates your work? Insight

Research highlights External collaborations & national and international reports and policy Research led by the Centre for Infection Prevention and Management & NIHR HPRU in HCAI and AMR 2008 MSc in Infection Management at Imperial 2009 2010 Antibiotic Stewardship programmes – what’s missing. J Antimicrob Chemother. 2010 Nov;65(11):2275-7. 2011 Considering nurse’s role in antimicrobial stewardship. J Infect Prev. . 2011 Jan; 12(1):6-10. Behaviour Change Strategies to Influence Antimicrobial Prescribing – Systematic Review Clin Infect Dis. 2011 Oct;53(7):651-62. 2012 Optimisation of IP&C by use of behaviour change – a systematic review. Lancet Infect Dis. 2012 Apr;12(4):318-29. Health technology assessment report. Department of Health. Development and Implementation of a smartphone app in AMS. When the user is not the chooser: learning from stakeholder involvement in technology adoption decisions in IP&C. J Hosp Infect Jul;81(3):163-8. 2013 Understanding determinants of antimicrobial prescribing within hospitals: the role of prescribing etiquette. Clin Infect Dis. 2013 Jul;57(2):188-96. Antimicrobial stewardship programmes: the need for wider engagement. BMJ Qual Saf. 2013 Nov;22(11):885-7. UK 5 year Antimicrobial Resistance Plan Strategy 2013 – 2018, Department of Health Analysis of the development and implementation of a smartphone application for delivery of antimicrobial policy. J Antimicrob Chemother. 2013 Apr; 68(4):960-7. 2014 WHO AMR – Global report on surveillance Fragmentation of care in peripheral vascular catheter care. PLoS One. 2014 Jan 14;9(1): e86167. The role of behaviour change in AMS. Infect Dis Clin North Am. 2014 Jun;28(2):169-75. UK Commons Select Committee report on AMR Do smartphone applications in healthcare require governance? BMC Med. 2014 Feb 14;12:29. . 2015 Health Foundation Report: Infection prevention and control : lessons from acute care in England. Lancet series on AMR: Understanding the mechanisms and drivers of antimicrobial resistance. Lancet. 2015 Jan;387(10014):176-187. Lack of weight recording in patients being administered narrow therapeutic index antibiotics. BMJ Open. Apr 2;5(4):e006092. Collaboration with Norway: An antimicrobial stewardship programme. Antimicrob Resis Infect Control. 2015 Jun 4;4:24. Towards changing healthcare worker behaviours in IP&C. J Hosp Infect. 2015 Jun;90(2):126-34. Improving the design and reporting of behaviour change interventions in AMS. Int J Antimicrob Agents. 2015 Mar;45(3):203-12. PHE Publication: Literature review of behaviour change and antibiotic prescribing in healthcare settings Antimicrobial dosing in obesity. J Antimicrob Chemother. 2015 Oct;70(10):2906-12. 2016 AMS: are we failing in cross-specialty clinical engagement? J Antimicrob Chemother. 2016 Feb;71(2):554-9. A needs assessment study for optimising prescribing practice in secondary care junior doctors. BMC Infect Dis. 2016 Aug 30; 16(1):456. Review on AMR O’Neill Report Mapping AMS in undergraduate medical, dental, pharmacy, nursing and veterinary education. PLoS One 2016 Feb29;11(2):e0150056. Preventing bloodstream infection in children. What’s the CATCH? Lancet. 2016 Jul 30;388(10043):462-3. Promoting medical student engagement with AMS through involvement in undergraduate research. J Infect. 2016 Sep 9. pii:SO163-4453(16)30223-7. ESRC call for social science research into AMR What are factors driving antimicrobial resistance? Perspectives from a public event in London. BMC Infect Dis. 2016 Sep 2;16:465. Serious electronic games as behaviour change interventions. Antimicrob Resist Infect Control. 2016 Oct 12;5:34. General Assembly of the United Nations High-Level meeting on AMR Patient engagement with infection management in secondary care. BMJ Open. 2016 Oct 31;6(10):e011040. Coverage of AMS across UK Postgraduate training curricula. J Antimicrob Chemother. 2016 Nov;71(11):3284-3292 Information provision for antibacterial dosing in the obese patient. J Antimicrob Chemother. 2016 Dec; 71(12):3588-3592. Mapping decision pathways of acute infection. BMC Med. 2016 Dec 12;14(1):208. 2017 Cochrane systematic review on behaviour change interventions in AMS – due for publication in 2017 The effect of adding a mobile health intervention to a multimodal AMS programme – an interrupted time series study. In press, J Antimicrob Chemother. PHE Publication: embedding national antimicrobial prescribing and stewardship competences into curricula 2018

Nursing summit at Imperial 2017

Great Team Work