Copyright © 2002 American Medical Association. All rights reserved. From: Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual CareThe Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) JAMA. 2002;288(23):2998-3007. doi:10.1001/jama.288.23.2998 Figure Legend: All participants in ALLHAT-LLT were enrolled in the ALLHAT antihypertensivetrial. Eligibility data were not collected for nonrandomized screenees. Allrandomized participants were included in the analyses in the treatment groupto which they were randomized. Closeout was October 1, 2001, to March 31,2002. Date of download: 12/17/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual CareThe Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) JAMA. 2002;288(23):2998-3007. doi:10.1001/jama.288.23.2998 Figure Legend: LDL indicates low-density lipoprotein. The percentage decrease frombaseline is shown above each time point. To convert values to mmol/L, multiplyby 0.0259. Date of download: 12/17/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual CareThe Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) JAMA. 2002;288(23):2998-3007. doi:10.1001/jama.288.23.2998 Figure Legend: CHD indicates coronary heart disease; MI, myocardial infarction;RR, relative risk; and CI, confidence interval. Date of download: 12/17/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual CareThe Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) JAMA. 2002;288(23):2998-3007. doi:10.1001/jama.288.23.2998 Figure Legend: CHD indicates coronary heart disease; MI, myocardial infarction;RR, relative risk; CI, confidence interval; and LDL-C, low-density lipoproteincholesterol. To convert LDL-C to mmol/L, multiply values by 0.0259. The axesare plotted on a natural logarithmic scale. Subgroups of CHD at baseline andLDL levels in both plots were not selected a priori. In plot B, there is ablack/nonblack treatment interaction (P = .03). Date of download: 12/17/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual CareThe Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) JAMA. 2002;288(23):2998-3007. doi:10.1001/jama.288.23.2998 Figure Legend: Log odds ratios (ln OR) and 95% confidence intervals for active treatmentvs control for 9 large statin trials (Table5) are compared with regression lines (solid) from meta-analysesof 45 long-term trials using statins and other cholesterol-lowering interventionspublished before December 31, 2000. Numbersinside data markers are references. Date of download: 12/17/2017 Copyright © 2002 American Medical Association. All rights reserved.