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© The Author(s) 2015. Published by Science and Education Publishing. Table 3. Effect of different treatments on catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and histological disease score Control UC patients before treatment UC patients treated with metformin UC patients treated with I3C UC patients treated with metformin/I3C combination Tissue CAT (μmol/g tissue) 2.23±0.0 5 0.89±0.04a (p=0.03) 1.53±0.05b (p=0.029) 1.4±0.06b (p=0.033) 1.81±0.05bcd (p1=0.025; p2=0.043; p3=0.04) Tissue MDA (nmol/g tissue) 18.3±0.7 43.1±0.81a (p=0.022) 28.51±0.5b (p=0.019) 26.4±0.8 b (p=0.018) 22.2±0.6bcd (p1=0.016; p2=0.032; p3=0.038) Tissue MPO (U/g tissue) 72.2 ±3.6 165.1±5.8a (p=0.02) 112.6±4.2b 123.4±4.15 b (p=0.037) 91.5±5.6bcd (p1=0.021; p2=0.042; p3=0.037) Tissue TNF-α (pg/mg protein) 67.4±4.1 385.6±9.6a (p=0.007) 195.3±7.4b (p=0.024) 253.2±8.1b (p=0.032) 149.8±6.3bcd (p1=0.018; p2=0.04; p3=0.032) Tissue TGF-β1 (pg/μg protein) 7.4±0.4 33.2±0.8a (p=0.016) 21.1±0.6b (p=0.035) 23.6±0.7 b (p=0.036) 16.2±0.4bcd (p1=0.016; p2=0.039; p3=0.035) Histological disease score 0.00 2.03±0.06a (p<0.001) 0.8±0.03b (p=0.023) 1.12±0.04b 0.54±0.03bcd (p1=0.015; p2=0.03; p3=0.04) a Significant compared to the control group (p<0.05) b Significant compared to UC patients before treatment (p<0.05) c Significant compared to UC patients treated with metformin (p<0.05) d Significant compared to UC patients treated with I3C (p<0.05) P1 refers to metformin/I3C combination group compared to UC patients before treatment; P2 refers to metformin/I3C combination g roup compared to UC patients treated with metformin; P3 refers to metformin/I3C combination group compared to UC patients treated with I3C. Ahmed M. Kabel et al. Effect of Indole-3-carbinol and/or Metformin on Female Patients with Ulcerative Colitis (Premalignant Condition): Role of Oxidative Stress, Apoptosis and Proinflammatory Cytokines. Journal of Cancer Research and Treatment, 2017, Vol. 5, No. 1, 1-8. doi:10.12691/jcrt-5-1-1 © The Author(s) 2015. Published by Science and Education Publishing.