Fistulizing pattern in Crohn's disease and pancolitis in ulcerative colitis are independent risk factors for cancer: A single-center cohort study Livia.

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Fistulizing pattern in Crohn's disease and pancolitis in ulcerative colitis are independent risk factors for cancer: A single-center cohort study Livia Biancone, Sara Zuzzi, Micaela Ranieri, Carmelina Petruzziello, Emma Calabrese, Sara Onali, Marta Ascolani, Francesca Zorzi, Giovanna Condino, Simona Iacobelli, Francesco Pallone Journal of Crohn's and Colitis Volume 6, Issue 5, Pages 578-587 (June 2012) DOI: 10.1016/j.crohns.2011.11.005 Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 1 Panel a. Cancer-free survival analysis showing that the occurrence of cancer over time did not significantly differ between CD and UC patients (Log-Rank test for the cancer-free survival p=0.21). Accordingly, the incidence rate of cancer did not significantly differ between CD and UC (4.6/1000pt/year vs 2.9/1000pt/year in UC, respectively; p=0.138). Panel b. When the analysis was restricted to non-smokers, the incidence of cancer was significantly higher in CD vs UC (6.2/1000pt/year vs 1.8/1000pt/year, p=0.0053 for the crude rates, p=0.0107 for the cancer-free survival probabilities). Journal of Crohn's and Colitis 2012 6, 578-587DOI: (10.1016/j.crohns.2011.11.005) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 2 Cancer-free survival analysis showing that the incidence of cancer was significantly higher in patients with fistulizing CD when compared to patients with inflammatory or fibrostricturing CD (overall differences for the cancer-free survival curves: p=0.001). Journal of Crohn's and Colitis 2012 6, 578-587DOI: (10.1016/j.crohns.2011.11.005) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 3 Panel a. Cancer-free survival analysis showing that in UC cancer was significantly more frequent in patients ≥40years vs <40years old (from the comparison of cancer-free survival probabilities, Log-Rank test p=0.0011; RR=4.6). Panel b. The impact of UC extent was not statistically significant (Log-Rank test p=0.110) due to similarity between distal and subtotal UC (rates per 1000pt/year: distal 2pt/year, subtotal 3.4pt/year p=0.52). Nevertheless, the difference was statistically significant between both distal UC vs pancolitis (rates per 1000pt/year: distal 2pt/year, pancolitis 6.8pt/year p=0. 0.0156) and between subtotal UC vs pancolitis (rates per 1000pt/year: distal 3.4pt/year, pancolitis 6.8pt/year p=0.045). Multivariate Cox model also showed a significant association between pancolitis and an increased cancer risk [pancolitis vs distal UC: HR=2.79 (95% CI 1.05–7.40); p=0.0396]. Journal of Crohn's and Colitis 2012 6, 578-587DOI: (10.1016/j.crohns.2011.11.005) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions