Sexuality and Quality of Life in Congenital Hypogonadisms Camil Castelo-Branco Hospital Clínic. University of Barcelona

Turner’s Sd. Multidisciplinary Team Gynecological Endocrinology Unit Camil Castelo-Branco Cristina Ros Joan Balasch Rhinology Unit and Smell Clinic Isam Alobid Joaquim Mullol Silvia Centellas Cytogenetics and Clinical Genetics Unit Ester Margarit Anna Serra Department of Neurophysiology Joan Santamaria Anna Tercero Department of Cardiology Paula Dantas Steroids lab Gregori Casals Dept. Psychiatry Esther Gómez Teresa Godás Department of Endocrinology Irene Halperin

Populations who may experience female sexual dysfunction (FSD): Abused Perimenopausal Pregnancy Multiple sclerosis Childhood sex abuse Chemotherapy Genital mutation Post menopausal Lack of sensitivity Gynecological cancer Radiation Battered Neurogenic disease Sexual trauma Spinal cord injury Vascular disease Post-hysterectomy Post-partum (Brassil et. al, 2002)

Statistics Different epidemiologic studies on FSD suggested that up to 49% of women experienced sexual dysfunction. Blümel JE, Castelo-Branco C et al. Menopause. 2004;11(1):78-81. Castelo-Branco C, Blumel JE, et al.J Obstet Gynaecol. 2003 Jul;23(4):426-30. TS represent < 0.03% General population Castelo-Branco C. Maturitas. 2014 Dec;79(4):471-5. Ros C & Castelo-Branco C. Gynecol Endocrinol. 2012 Sep;28(9):726-32. US population data revealed that 9.7 million women (50-74 y) self-report complaints of diminished vaginal lubrication, pain and discomfort with intercourse, decreased arousal, and difficulty achieving orgasm. Berman J et al. Urology. 1999;54(3):385-91

Etiology “The etiologies of female sexual dysfunction affect a variety of populations and may be caused by psychological, emotional, or physiological reasons. Often, the etiology is multifactorial & interrelated.” Castelo-Branco C et al. Expert Opin Ther Patents. 2007;17(6):639-647

Etiology: Psychological Causes As with most disorders, female sexual dysfunction can be caused and aggravated by psychological causes. (Sexual or) Emotional Abuse Depression Relationship Issues Stress Self Esteem