Multi-unit Abutment Plus Improvement to the All-on-4® treatment concept workflow For Conical Connection Implants GMT XXXX GB 1702 © Nobel Biocare Services AG, 2017. All rights reserved. Nobel Biocare, the Nobel Biocare logotype and all other trademarks are, if nothing else is stated or is evident from the context in a certain case, trademarks of Nobel Biocare. Please refer to nobelbiocare.com/trademarks for more information. Product images are not necessarily to scale. Disclaimer: Some products may not be regulatory cleared/released for sale in all markets. Please contact the local Nobel Biocare sales office for current product assortment and availability. For prescription use only. Caution: Federal (United States) law restricts this device to sale by or on the order of a licensed dentist. See Instructions for Use for full prescribing information, including indications, contraindications, warnings and precautions.

Increasing market potential due to aging population UN projects world population to reach 9.7 billion by 2050 First time in history with the number of persons aged 65+ expected to outnumber children under 5 by the end of this decade. UN projects world ageing population to reach 2.1 billion by 2050 Life expectancy to reach 77.1 by 2050 (vs. 48 in 1950)

Growing number of edentulous people worldwide Fully edentulous population in the Western World: 40 million 6-10% of the world´s population is estimated to be edentulous Close to 300 million people in the Western World and Asia are estimated to be edentulous Few of those affected by tooth loss end up receiving implant treatment  highly underpenetrated market Fully edentulous population in Asia: 250 million Source: iData 2012/2013 (aggregated data from EU, US, APAC, BR, CH), Straumann Research 2011

Treatment of the soon-to-be edentulous patient Nobel Biocare provides the broadest and most compelling offering for the edentulous patient Overdenture + Locators All-on-4 Bridge + 5-6 implants Bar + implants Bridge + 5-6 implants

The All-on-4® treatment concept The All-on-4® treatment concept is a cost efficient, graftless solution that provides patients with a fixed full-arch provisional prosthesis on the day of surgery * Only four implants for full arch rehabilitation Graftless procedure / Minimally invasive Immediate Function (fixed provisional acrylic bridge) Flap or flapless approach Up to 45º tilting of the posterior implants * If patient criteria are met and adequate stability achieved Note: Image shows the Multi-unit Abutment All-on-4 is an efficient treatment for the fully edentulous patients, developed by Nobel Biocare in collaboration with Dr Paulo Malo, MaloClinic, Portugal. The All-on-4 solution is also a well documented solution with excellent study results and is today world-wide spread. Prerequisite – 30 degree angulated abutments Cost effective with acrylic bridges Scientific evidence– A number of publications support the concept and has been publiched over the years. 10 year results in the mandible just resently published. 5 year data for maxilla in preparation. Many ways of selling this product. Decreased number of implants resulting in reduced costs for patients Flapless procedure for the TSP or not so trained dentists Graftless procedure resulting in less patients and costs for the patients Immediate function for soon to be edentulous patients. They don’t have to walk out without teeth 45º tilting of the posterior implants allow to place implants in anterior bone when no posterior bone is available 45º tilting of the posterior implants allows to reduce cantilever and provide 12 teeth Tilting of implants increase the Bone to implant contact resulting in the bi-cortical anchorage of the apex in the hard bone

The All-on-4® treatment concept Benefits for the clinician Treatment option for edentulous patients and soon-to-be edentulous Immediate esthetic and function for the patient with the provisional restoration Graftless approach Clinically validated and scientifically proven Step by step surgical and prosthetic procedure Many ways of selling this product. Decreased number of implants resulting in reduced costs for patients Flapless procedure for the TSP or not so trained dentists Graftless procedure resulting in less patients and costs for the patients Immediate function for soon to be edentulous patients. They don’t have to walk out without teeth 45º tilting of the posterior implants allow to place implants in anterior bone when no posterior bone is available 45º tilting of the posterior implants allows to reduce cantilever and provide 12 teeth Tilting of implants increase the Bone to implant contact resulting in the bi-cortical anchorage of the apex in the hard bone

Multi-unit abutment – restorative simplicity Pre-mounted holder for easy handling Ideal for small Space: Short cone for limited intraoclusal space Secure passive fit: wide Shoulder for easy positioning of the prosthetic restoration Rotational locking for easy repositioning Note: Image shows the Multi-unit Abutment

Multi-unit Abutment Plus – the next generation The innovative update to the Multi-unit Abutment Multi-unit Abutment Multi-unit Abutment Plus

Multi-unit Abutment Plus New straight and angled Multi-unit Abutments Plus for conical connection New Temporary Snap Coping Updated Protection Analogs and Abutment Replicas Straight and Angled Multi-unit Abutments Plus Temporary Snap Coping and Drill Guide for MUA Plus NOTE FOR THE SPEAKER: New Multi-unit Abutments Plus are compatible with the previous Temporary Copings New Temp Snap Copings are NOT compatible with the previous Multi-unit Abutments Need list of articles

Multi-unit Abutment Plus – the next generation Small change – Big improvement Temporary Snap Coping Radical simplification of chair side denture conversion No need for screw fixation during try-in and adjustment phase Ease of use for the benefit of the patient and the clinician Add clinician comment on “Time saving” chairside

Multi-unit Abutment Plus – the next generation Small change – Big improvement Drill Guide for MUA Plus Radical simplification of chair side denture conversion No need for screw fixation during try-in and adjustment phase Ease of use for the benefit of the patient and the clinician Add clinician comment on “Time saving” chairside

FAQ’s on compatibility INFORMATION FOR THE SPEAKER  The Temporary Snap Coping is only compatible with the Multi-unit Abutment Plus. The Temporary Coping Multi-unit (29046) will continue to be available and can be used on all Multi-unit abutments. Anything that goes on top of the Multi-unit abutment goes on top of Multi-unit abutment Plus. Protection Analogs Multi-unit (29123) have been updated with new MUA plus design and can be used with old and new Temporary Copings. Abutment Replicas Multi-unit (31161/29110) have been updated with new MUA plus design and can be used with old and new Temporary Copings. If a customer is ordering the new Temporary Snap Coping, he should ideally replace his Replicas and Protection Analogs to the new MUA Plus updated articles. Need list of articles

Marketing and sales support Include the material available for the speaker Instructional material All-on-4 manual (update with surgical + restorative flow) MUA Plus quick guide – conversion of existing denture MUA Plus product description Demo material MUA Plus denture conversion animation Clinical cases Video/ text user testimonials Demo models: new Temp denture for existing All-on-4 show model + acrylic block