Copyright © 2004 American Medical Association. All rights reserved. From: Corticospinal Physiology in Patients With Prader-Willi SyndromeA Transcranial Magnetic Stimulation Study Arch Neurol. 2004;61(10):1585-1589. doi:10.1001/archneur.61.10.1585 Figure Legend: Grouped values of relaxed motor threshold, intracortical inhibition, and intracortical facilitation. A, The relaxed motor threshold was significantly (P<.05) higher in the whole Prader-Willi syndrome (PWS) group than in controls. B, Intracortical inhibition was similar in both the PWS group and the control group. Intracortical facilitation was significantly reduced among patients with PWS (P<.001). C, The PWS group is split into patients with a deletion and patients with a uniparental disomy. Intracortical inhibition was significantly less (that is, its nominal value was higher) in patients with a deletion than in those with a uniparental disomy (P<.05). For intracortical facilitation, both subgroups showed a similar reduction as compared with controls (P< .01). White column indicates patients with PWS and a deletion; gray column, patients with PWS and a uniparental disomy; black column, controls; bar, standard deviation; and asterisk, statistically significant differences. Date of download: 12/19/2017 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Corticospinal Physiology in Patients With Prader-Willi SyndromeA Transcranial Magnetic Stimulation Study Arch Neurol. 2004;61(10):1585-1589. doi:10.1001/archneur.61.10.1585 Figure Legend: Typical example of the paired transcranial magnetic stimulation effects in a control subject, in a patient with Prader-Willi syndrome and a deletion, and in a patient with Prader-Willi syndrome and a uniparental disomy. Each tracing represents the average of at least 12 control (dotted line) and 12 conditioned (black line) motor evoked potentials. A, Interstimulus interval, 3 ms; the patient with a deletion shows less inhibition than the remaining 2 subjects. B, Interstimulus interval, 16 ms; facilitation is depressed in both patients as compared with the control. Date of download: 12/19/2017 Copyright © 2004 American Medical Association. All rights reserved.