FASD in San Diego, Moscow, and Helsinki Sarah Mattson, PI Collaborative Initiative on Fetal Alcohol Spectrum Disorders PI Progress Meeting February 2006

Collaborators San Diego Moscow Helsinki Sarah Mattson Edward Riley Galina Marintcheva Valentina Konovalova Tatiana Riazanova Helsinki Ilona Autti-Rämö Marit Korkman Åse Fagerlund

Summary of Progress Dysmorphology = 299+ cases 74 SD; 140 Helsinki; 85+ Moscow 3D Facial Imaging = 193 cases 70 SD; 123 Helsinki Neurobehavioral = 248 cases 76 SD; 136 Helsinki; 34 Moscow Imaging = 50 cases 30 SD (MRI); 20 Helsinki (MRS) Updated 1/06

Demographic Information San Diego Helsinki Moscow FASD CON CONT N 37 36 76 40 30 27 7 Sex (% Female) 43.2 44.4 59.2 55.0 53.3 28.6 Ethnicity (% White) 64.9 72.2 100 Race (% Hispanic) 18.9 19.4 N/A SES (M +/- SD) 46.5 +/- 12.9 50.9 +/- 11.9 Age (M +/- SD) 13.1 +/- 3.0 12.1 +/- 2.82 13.3 +/- 3.6 13.5 +/- 3.6 13.3 +/- 2.9 15.3 +/- 1.6 15.3 +/- 1.1 FSIQ (M +/- SD) 91.1 +/- 12.8 96.7 +/- 18.6 74.1 +/- 10.4 79.0 +/-9.4 Updated 1/06

Edinburgh Score closer to 1.0 = “more” right handed. Scores closer to -1 = more left handed. Updated 1/06

General Intellectual Functioning Leiter Brief IQ WISC-III Raven’s SPM

Overall Mean IQ Score Comparison Updated 1/06 Just SD

Individual IQ Score Comparison Correlation is .53 Updated 1/06 Just SD

Questionnaires & Rating Scales Disruptive Behavior Disorder Rating Scale (Pelham) Sluggish Cognitive Tempo (McBurnett & Pfiffner) Child Behavior Checklist, Teacher Rating Form, Youth Self Report (Achenbach) Pictorial Depression Scale

DBD Parent-Teacher Rating Scale San Diego Helsinki FASD CON CONT % ADHD- Inattentive Subtype 64.9 2.9 36.0 26.7 11.8 H/I Subtype 37.8 0.0 32.0 6.7 % ODD 48.7 16.0 20.0 % CD 24.3 4.0 5.9 Updated 1/06

Sluggish Cognitive Tempo Updated 1/06

Pictorial Depression Scale Add picture

Pictorial Depression Scale N >10 (SD) FASD = 14 (37.8%) CON = 9 (25%) A cut off of >10 indicates clinical significance Updated 1/06 Cutoffs are just SD 14/37 (37.8%) FASD >10 9/36 (25%) Controls >10

Nonverbal Learning & Memory Virtual Water Maze CANTAB Pattern and Spatial Recognition Spatial Span Spatial Working Memory

VWM Time Spent in NE Quadrant Total N FASD = 72 CON = 53 CONT = 20 Updated 1/06 These are Means from SD, Finland, Moscow Total N = 72 FASD, 53 CON, and 20 CONTRAST San Diego, Helsinki, & Moscow

VWM Total Latency to Find Platform Total N FASD = 72 CON = 53 CONT = 20 Updated 1/06 San Diego, Helsinki, & Moscow

VWM Path Length (Relative to Pool Diameter) Total N FASD = 72 CON = 53 CONT = 20 Updated 1/06 San Diego, Helsinki, & Moscow

CANTAB Recognition Memory Updated 1/06 San Diego & Moscow San Diego & Moscow

CANTAB Spatial Span New 1/06 SD & Moscow San Diego & Moscow

CANTAB Spatial Working Memory New 1/06 SD and Moscow San Diego & Moscow

Attention Attention Sustained (Leiter) NES-3

Leiter Attention Sustained Updated 1/06 Just SD

NES-3 CPT Single Following Repeating Cat Wolf followed by a Cat e.g., cat-cat, pig-pig NES#: D/c testing: Total (Russia and SD) = 3 in FASD (2 Russia, 1 SD), 1 in control (1 Russia). SM-I don’t know where you got these numbers so I left them alone.

CPT - Following Updated 1/06 Just SD Reaction Time Accuracy Errors

Executive Function Verbal Fluency (DKEFS) Trail Making (DKEFS) Progressive Planning Test (Kodituwakku) Reversal Learning (Kodituwakku)

Verbal Fluency Updated 1/06 Letter - Category is scaled score for difference. Score < 10 = letter < Category Just SD

Trail Making Updated 1/06 Just SD

Progressive Planning Test (Counts) New 1/06 Just SD 1st Trial = cards correct on 1st trial All Trials = cards correct no matter if trial 1, 2, or 3 Level 1 = cards correct on items 1-4, no matter what trial Level 2 = cards correct on items 5-8, no matter what trial (Level 2 cards have 1 more manipulation, i.e., an extra bead, than Level 1 cards)

Reversal Learning Total N FASD = 43 CON = 40 San Diego & Moscow Updated 1/06 San Diego & Moscow 1 SD subject was discontinued after the 1st reversal, because they did not get it after >100 trials. San Diego & Moscow

Current Projects McGee, C.L., Vaurio, L.E., Mattson, S.N., Riley, E.P., Marintcheva, G., Konovalova, V. (2006). Wisc subtest performance in Russian children with fetal alcohol syndrome and IQ-matched controls. Submitted to RSA 2006. Vaurio, L.E., McGee, C.L., Kane, A. Riley, E.P., Marintcheva, G., Konovalova, V., and Mattson, S.N. Relationship of IQ and WCST performance in children with fetal alcohol syndrome. Manuscript in preparation.

Plans for 2006 Continue collecting data: San Diego & Moscow Score & verify protocols: All sites Enter data into neuro input tool Submit Abstracts to RSA & ISBRA