Professor of oncology Faculty of medicine Anthracyclines Presented by: Dalia Refat Marwa el-ashwah Noha el-bassiouny Nortan Hashad Samer EL-rouweny and Yomna Mamdouh Supervised by: Proff.Nashaat Lotfy Professor of oncology Faculty of medicine

Content: Definition Mechanism of action Indications

Definition: It’s a class of antineoplastic antibiotics. The first anthracycline discovered was daunorubicin (trade name Daunomycin), which was produced naturally by Streptomyces bacteria. Doxorubicin (Adriamycin) was developed shortly after, and many other related compounds have followed.

Daunorubicin Doxorubicin Epirubicin Idarubicin Valrubicin Mitoxantrone Trade name Drug Daunomycin, Daunoxome Daunorubicin Adriamycin, Doxil Doxorubicin Pharmorubicin Epirubicin Zavidos Idarubicin Valstar Valrubicin Novantrone Mitoxantrone Bleocin Bleomycin

Mechanism of action: They are Non Cell Cycle specific antibiotics, that act on S and G2 phase.

Through three mechanisms: Intercalate into DNA resulting in inhibition of it’s synthesis and function. Inhibits topoisomerase II enzyme by forming a cleavable complex with DNA and topoisomerase II to create uncompensated DNA helix leading to DNA breakage.

Formation of cytotoxic oxygen free radicals results in single and double stranded DNA breakage.

AIDS-related Kaposi’s sarcoma Indications: Doxorubicin and Daunorubicin Acute leukemia, Hodgkin's and non Hodgkin’s lymphoma. Doxorubicin (liposomal form) AIDS-related Kaposi’s sarcoma Ovarian cancer

Epirubicin Breast Cancer Idarubicin Hematological disorder (AML) Valrubicin Bladder Cancer Mitoxantrone Metastatic Breast Cancer, Leukemia and Prostatic Cancer

Bleomycin Squamous cell carcinoma, lymphoma and Testicular carcinoma