Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity  Cristian O'Flaherty, Ph.D., Barbara F. Hales, Ph.D., Peter Chan, M.D., Bernard Robaire, Ph.D.  Fertility and Sterility  Volume 94, Issue 4, Pages 1374-1379 (September 2010) DOI: 10.1016/j.fertnstert.2009.05.068 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Sperm parameters in patients with cancer and community volunteers. Community volunteers (n = 9–11); patients with testicular cancer (n = 8–16); patients with Hodgkin lymphoma (n = 8–16). ∗Values significantly lower compared with community volunteers at each given time point (Mann-Whitney rank sum test; P≤.05). #Values significantly different compared with values at 0 months within each group (paired t-test or the Wilcoxon signed-rank test; P≤.05). Fertility and Sterility 2010 94, 1374-1379DOI: (10.1016/j.fertnstert.2009.05.068) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Follicle-stimulating hormone, LH, and testis volume in patients with cancer and community volunteers. (A) FSH. (B) LH. (C) Testis volume. Community volunteers (n = 6–11); patients with testicular cancer (n = 11–13); patients with Hodgkin lymphoma (n = 6–12). ∗Values significantly lower compared with community volunteers at each given time point (Mann-Whitney rank sum test; P≤.05). #Values significantly different compared with value at 0 months within each group (paired t-test or the Wilcoxon signed-rank test; P≤.05). Fertility and Sterility 2010 94, 1374-1379DOI: (10.1016/j.fertnstert.2009.05.068) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Sperm DNA damage in patients with cancer and community volunteers. Community volunteers (n = 8–11); patients with testicular cancer (n = 7–13); patients with Hodgkin lymphoma (n = 4–13). ∗Values significantly lower compared with community volunteers at each given time point (Mann-Whitney rank sum test; P≤.05). #Values significantly different compared with value at 0 months within each group (paired t-test or the Wilcoxon signed-rank test; P≤.05). Fertility and Sterility 2010 94, 1374-1379DOI: (10.1016/j.fertnstert.2009.05.068) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions