NIHR University College London Hospitals and UCL Biomedical Research Centre Professor Bryan Williams Chair of Medicine UCL Director; NIHR UCLH/UCL Biomedical Research Centre, Director; Research & Development UCL Hospitals University College London bryan.williams@ucl.ac.uk

Our vision In five years our BRC partnership will be a world leading Professional Translational Research Organisation Accelerating patient access to medical innovation VISION

World class Discovery Science 1 NIHR/RAND metrics – biggest aggregation of biomedical science in Europe World class Discovery Science UK REF 2014 research power and research impact 1 World ranking for preclinical and clinical science (Times Higher 2015) 4 Over 700 BRC publications 2015/16, rising from 200 in 2012 (current BRC H-Index 96, 55,000 citations) Francis Crick Institute founding partner and its natural translational partner VISION

University / NHS Partnership Alignment of UCL Research Strength with UCLH Clinical Excellence World Class discovery science UCLH is a research hospital A Strong University / NHS Partnership Joint capital clinical / research investment in next 5 years £1.5bn Unparalleled access to patients with rare and complex diseases VISION

20:20 VISION World Class discovery science Largest innovative/complex early phase research program in Europe 3-fold increase in phase I / II trials since 2012; and growing exponentially A Strong University / NHS Partnership Leading in UK: MRC early phase trials awards (DPFS) – 25% of all awards Explicit Focus on Experimental Medicine and Translation Leading in Europe: UCL top for Horizon 20:20 awards in Health 20:20 VISION

1 VISION Harnessing technological innovation Transforming drug discovery, target identification and validation Computer science Healthcare Engineering and Imaging (REF2014) High Through-Put Platforms (genomic, omic, imaging) with Patient Data linked at scale UCL Farr Institute – Data Science (Only BRC-affiliated University with a Farr Institute) Partnership with the Alan Turing Institute, Google Deep Mind, eMedLab and EBI eMedLab – high performance computing cluster for genomic, imaging and patient data VISION

3 £100m £100m £600m VISION High Through-Put Platforms (genomic, omic, imaging) with Patient Data linked at scale TREACC – Professional support for Translational Research and commercialisation £100m Syncona investment into UCL in past year Enterprise culture Industry Partnerships Creating Value UCL Technology and Apollo Start-up funds £100m Leveraged in current BRC in 5 years (£8:1) £600m Major Pharma embedded industry partners for drug discovery (Takeda, Eisai, and GSK) 3 VISION

VISION High Through-Put Platforms with Patient Data linked at scale (genomic, omic, imaging) with Patient Data linked at scale Enterprise culture Industry Partnerships Creating Value The BRC Experimental Medicine Academy BRC supported PhD students increasing from 101 (2012) to 315 (2015) >90% conversion to fellowships Building Resilience Training the next generation of Experimental Medicine Leaders VISION

THEMES Existing Themes New Themes Cross-cutting Themes 1 3 NIHR University College London Hospitals / UCL Biomedical Research Centre BRC Director Bryan Williams Existing Themes Neuroscience Nicholas Wood Dementia Martin Rossor Cancer David Linch Immunity, Inflammation & Immunotherapeutics Emma Morris Cardiovascular Aroon Hingorani 1 3 Robert Howard Mental Health Anne Schilder Deafness and Hearing New Themes Stefano Fedele Oral Health & Disease Sharon Peacock Infection & Antimicrobial Resistance Rachel Batterham Obesity Cross-cutting Themes Health Care Engineering and Imaging Health Care Informatics, Genomics, “-omics” & Data Science BRC Education and Training Program – The BRC Academy Translational Research and Enterprise Accelerator (TREACC) Public Involvement, Engagement and Communications UCL Therapeutic Innovation Network Bart Vanhaesebroeck Sebastian Ourselin Harry Hemingway Geraint Rees David Lomas Simon Denegri THEMES

UCLH UCL BRC RESEARCH ECOSYSTEM Global National Patients Pan UCL NIHR UCLH CRF Sir Francis Crick Institute Farr Institute for Informatics Alan Turing Institute UCL Computer Science Google Deep Mind UCL Partners Academic Health Sciences Centre UCL 7 MRC Centres Wolfson and Alzheimer’s UK Drug Discovery Institutes BRC Academy in Experimental Medicine Bloomsbury Research Institute Cancer Research UK Centre Embedded Industry Partnerships Discovery Science Global Academic Industry Partnerships Clinical Translation Genomics Proteomics Metabolomics Patient & Public Involvement & Engagement Patients National Pan-NIHR Bioresource TRCs NIHR HIC Imaging & Health Care Engineering Translational Research & Enterprise Accelerator Health Care Informatics & Data Science Pan UCL AHSC GOSH BRC Moorfields BRC Therapeutic Innovation Networks BRC RESEARCH ECOSYSTEM

World Class Science Transforming Patients’ Lives 1000 new phase I/II Trials Accelerating Patient Access 1000 new phase I/II Trials Accelerating Patient Access Vanguard treatments for Cancer Proton Beam National Centre for Cancer Immunotherapy Vanguard treatments for Cancer Proton Beam National Centre for Cancer Immunotherapy Genomics / omics platforms with patient data linkage at scale Innovating and Repurposing Applied engineering for diagnostics and imaging precision medicine Create 30 new companies new treatments for many previously intractable diseases Create 30 new companies new treatments for many previously intractable diseases Innovative treatments for dementia and neurological diseases Identifying and Targeting the disease pro-drome Innovative treatments for dementia and neurological diseases Identifying and Targeting the disease pro-drome Embedded industry partnerships - drug discovery the human as the experimental model Embedded industry partnerships - drug discovery the human as the experimental model Disruptive innovation in Cellular and Gene therapies the leading centre in Europe Disruptive innovation in Cellular and Gene therapies the leading centre in Europe Applied engineering for diagnostics and imaging precision medicine Applied engineering for diagnostics and imaging precision medicine Inward investment We will leverage £1bn Creating Health and Wealth Inward investment We will leverage £1bn Creating Health and Wealth WHAT WE WILL DELIVER