Nerve MUSCLE PHYSIOLOGY

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Presentation transcript:

Nerve MUSCLE PHYSIOLOGY

Dystrophin-Glycoprotein Complex Merosin

Dystrophin-Glycoprotein Complex Large Protein= 427000 Forms a rod which connects the actin filament to the transmembrane protein Beta-Dystroglycan in the sarcolemma. Function Add strength to the muscle by providing a scaffolding for the fibrils and connecting them to the Extra cellular matrix

ACTIN FILAMENTS Composed of three Protein components: 1. F-Actin strands formed by G-Actin Globular Proteins. MW = 42,000 2. Tropomyosin. - M W =70,000 3. Troponin ,comprised of 3 subunits a. Troponin-T b. Troponin-I c. Troponin-C G-Actin F-Actin

Components of Actin Filaments G- F-

ACTIN FILAMENTS RELAXED EXCITED

Myosin filaments Comprised of multiple Myosin Molecules M W = 480,000 Each Myosin Molecule is formed by: Heavy Chains - MW 200,000 (Two) Light Chains – MW 20,000 (Four)

MYOSIN FILAMENTS Heavy Chain

CROSS SECTION OF SARCOMERE

Muscle Contraction (Active sites Exposed) Relaxed Contracted

Interaction B/W Actin & Myosin

Walk Along Theory

Walk Along (Ratchet) Theory

Relaxed & Contracted