Figure 1. Melatonin levels in CSF of control subjects (n = 82) and AD patients (n = 85). *, P< 0.0001. Decreased Melatonin Levels in Postmortem Cerebrospinal.

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Figure 1. Melatonin levels in CSF of control subjects (n = 82) and AD patients (n = 85). *, P< 0.0001. Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype1 J Clin Endocrinol Metab. 1999;84(1):323-327. doi:10.1210/jcem.84.1.5394 J Clin Endocrinol Metab | Copyright © 1999 by The Endocrine Society

Figure 2. Melatonin levels in CSF of control subjects, 41–80 yr of age (n = 53) and older than 80 yr (n = 29). *, P < 0.01. Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype1 J Clin Endocrinol Metab. 1999;84(1):323-327. doi:10.1210/jcem.84.1.5394 J Clin Endocrinol Metab | Copyright © 1999 by The Endocrine Society

Figure 3. Melatonin levels in CSF of control subjects and AD in relation to the clock time of death. Note that the overall levels of melatonin in AD were significantly lower than those in controls and that there was no obvious day/night rhythm in CSF melatonin levels in either controls or AD patients. Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype1 J Clin Endocrinol Metab. 1999;84(1):323-327. doi:10.1210/jcem.84.1.5394 J Clin Endocrinol Metab | Copyright © 1999 by The Endocrine Society

Figure 4. Melatonin levels in CSF in control subjects and AD in relation to the month of death. Note that there was no significant seasonal rhythm in CSF melatonin levels in either controls or AD patients. Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype1 J Clin Endocrinol Metab. 1999;84(1):323-327. doi:10.1210/jcem.84.1.5394 J Clin Endocrinol Metab | Copyright © 1999 by The Endocrine Society

Figure 5. Melatonin levels in CSF of AD patients who expressed ApoE-∈3/4 (n = 32) and ApoE-∈4/4 (n = 17). *, P < 0.02. Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype1 J Clin Endocrinol Metab. 1999;84(1):323-327. doi:10.1210/jcem.84.1.5394 J Clin Endocrinol Metab | Copyright © 1999 by The Endocrine Society