Small section of the neocortex from a patient with Alzheimer disease showing two classical neuropathologic lesions of the disease. A. The modified silver.

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Small section of the neocortex from a patient with Alzheimer disease showing two classical neuropathologic lesions of the disease. A. The modified silver staining shows one dense senile (amyloid) plaque indicated by three arrowheads. The plaque consists of aggregated extracellular deposits of amyloid β-peptide (Aβ) fragments surrounded by silver-positive dystrophic neurites. The arrow indicates a neuron containing neurofibrillary tangles, which appear as dark masses of abnormal filaments occupying most of the cytoplasm. B. The image shows higher magnification of two neurons containing neurofibrillary tangles (indicated by arrows). (Photograph courtesy of Shahriar Salamat, MD, PhD, University of Wisconsin School of Medicine and Public Health, Department of Pathology and Laboratory Medicine.) Source: Dementia Including Alzheimer Disease, Hazzard's Geriatric Medicine and Gerontology, 7e Citation: Halter JB, Ouslander JG, Studenski S, High KP, Asthana S, Supiano MA, Ritchie C. Hazzard's Geriatric Medicine and Gerontology, 7e; 2017 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/Books/1923/haz7e_ch66_f001.png&sec=144523776&BookID=1923&ChapterSecID=144523735&imagename= Accessed: December 21, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved