Group on Neural Issues

Outline Key gaps in knowledge Barriers and opportunities Methodological needs Research priorities for the future

1. Key gaps in knowledge

1. Key gaps in knowledge Biological changes with exercise in humans Can these changes provide biomarkers Determinants of rate of recovery Characteristics of effective exercise Gender, race, culture-dependent efficacy How best to promote brain health Education? Incentives? Penalties? Special requirements for people at high risk Education of legislators, policy makers

2. Barriers and opportunities a. Barriers

2. Barriers and opportunities a. Barriers Finer distinctions Measurements of deficits Design of Rx “Reverse translation:” Bedside to bench Need to expand considerations of mood (depression is only one facet)

2. Barriers and opportunities b. Opportunities

2. Barriers and opportunities b. Opportunities Large clinical trials Data sets Ongoing or planned Professional meetings (provide education)

3. Methodological needs

3. Methodological needs How to influence behavior? (and when?) More precise Rx Tracking compliance Better scales to measure Prediction of responders to given treatment Can genomics help? Personality traits Impact

4. Research priorities

4. Research priorities What is impact of interventions, combos Neurobiological Clinical How large is the problem? Personal and Societal What are the risk factors? Identification of biomarkers (risk, impact) Make better use of ongoing trials Why low compliance? How to promote behavior for healthy brain?