Gamma Delta T Cell Reconstitution Is Associated with Fewer Infections and Improved Event-Free Survival after Hematopoietic Stem Cell Transplantation for.

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Gamma Delta T Cell Reconstitution Is Associated with Fewer Infections and Improved Event-Free Survival after Hematopoietic Stem Cell Transplantation for Pediatric Leukemia Ross Perko, Guolian Kang, Anusha Sunkara, Wing Leung, Paul G. Thomas, Mari H. Dallas Biology of Blood and Marrow Transplantation Volume 21, Issue 1, Pages 130-136 (January 2015) DOI: 10.1016/j.bbmt.2014.09.027 Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Reconstitution of γδ T cells and risk for infection. Infection was defined as a positive culture or PCR for a pathogen in association with a clinical illness. Patients were surveyed weekly with galactomannan assay and PCR for cytomegalovirus, Epstein-Barr virus, and adenovirus as previously described [24]. Additional cultures for suspected pathogens were obtained when clinically indicated. (A) Each point represents a patient and the documented maximum γδ T cell value in the first year after HSCT. The mean value of γδ for patients with no documented infections (ξ) is compared with the mean value of γδ for patients with documented infections (Ο). Infections are further depicted as bacterial, viral, or fungal infections. Error bar represents SEM. (B) The cumulative incidence (CI) of infection is shown for patients in the low/normal (- -) or high (—) γδ T cell group. Biology of Blood and Marrow Transplantation 2015 21, 130-136DOI: (10.1016/j.bbmt.2014.09.027) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Survival estimates for patients in low/normal and high γδ T cell group. The Kaplan-Meier estimates for (A) disease-free survival, (B) EFS, and (C) OS are compared between patients with low/normal (- -) or high (—) γδ T cell group. Biology of Blood and Marrow Transplantation 2015 21, 130-136DOI: (10.1016/j.bbmt.2014.09.027) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions