A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single.

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A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single aneuploidy and diploidy by five-color fluorescence in situ hybridization using one probe set  Hatice Gul Durakbasi-Dursun, Ph.D., Ayse Gul Zamani, M.D.,Ph.D., Ruhusen Kutlu, M.D., Hüseyin Görkemli, M.D., Muhterem Bahce, M.D.,Ph.D., Aynur Acar, Ph.D.  Fertility and Sterility  Volume 89, Issue 6, Pages 1709-1717 (June 2008) DOI: 10.1016/j.fertnstert.2007.06.050 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The comparison of disomy frequencies (%) in patients with OAT and controls for examined chromosomes. Values are expressed as average ± SEM for controls and patients with OAT. ∗P<.001 represents the significance level between controls and patients with OAT. OAT = oligoasthenoteratozoospermia. Fertility and Sterility 2008 89, 1709-1717DOI: (10.1016/j.fertnstert.2007.06.050) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 The comparison of nullisomy frequencies (%) in patients with OAT and controls for examined chromosomes. Values are expressed as average ± SEM for controls and patients with OAT. ∗P<.001 represents the significance level between controls and patients with OAT. OAT = oligoasthenoteratozoospermia; SC = sex chromosome. Fertility and Sterility 2008 89, 1709-1717DOI: (10.1016/j.fertnstert.2007.06.050) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 The comparison of diploidy, single aneuploidy, double aneuploidy, and total aneuploidy frequencies (%) in patients with OAT and controls for examined chromosomes. Values are expressed as average ± SEM for controls and patients with OAT. ∗P<.001 represents the significance level between controls and patients with OAT. OAT = oligoasthenoteratozoospermia; D = diploidy; SA = single aneuploidy; DA = double aneuploidy; TA = total aneuploidy (single aneuploidy + double aneuploidy). Fertility and Sterility 2008 89, 1709-1717DOI: (10.1016/j.fertnstert.2007.06.050) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions