Synthesis and cytotoxicity evaluation of hydroquinazolinone derivates Faillace, M. S.1, Brito, M. R. M.2, Militão, G. C. G.3, Costa, J. P.2, Silva, A. P. S. C. L.2, Peláez, W. J.1,* 1Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, XHUA5000, Córdoba, Argentina, *e-mail: waldemar31@fcq.unc.edu.ar 2Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI 64049550, Brazil. 3Laboratory of Bioassays for Drug Research, Federal University of Pernambuco, Recife, PE 50670-901, Brazil. Introduction Results and Discussion Furthermore, the cytotoxic activity was evaluated using three cancerous cell strains for different carcinomas. The cis/trans-2-thioxoquinazolin-4-ones and their 2,4-dione analogs were obtained by conventional synthesis in solution, being the trans isomers more stable than the cis analogs. In the synthesis process yielded nine different WPs denominated assets. These assets were synthesized by the vacuum pyrolysis method. The substitution of the ring with S, N, C and H groups gave it an antitumor activity, shown by all compounds studied. Table 1: Evaluation of antitumor activity of derivatives hidroquinazolinones. Material and Methods Cancer cell line culture assay Conclusion NCI-H MCF-7 HEP-2 Thus, it can be suggested that the WPs have antitumor activity in vitro tumor lines between those analyzed, but an advanced investigation is necessary before to be claimed. Antitumor activity Acknowledgements: