Cardiac Abnormalities in Children With Sickle Cell Anemia

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Presentation transcript:

Cardiac Abnormalities in Children With Sickle Cell Anemia Lucille A. Lester, M.D., Peter C. Sodt, M.D., Nancy Hutcheon, B.A., Rene A. Arcilla, M.D. CHEST Volume 98, Issue 5, Pages 1169-1174 (November 1990) DOI: 10.1378/chest.98.5.1169 Copyright © 1990 The American College of Chest Physicians Terms and Conditions

Figure 1 Comparison of observed left ventricular end-diastolic diameter of sickle cell anemia patients with corresponding predicted normal (left), and of left ventricular posterior wall thickness with corresponding predicted normal values (right). The points for SCA patients (x) are superimposed on the mean ± 2 standard deviation range of the predicted normal values for black control subjects. CHEST 1990 98, 1169-1174DOI: (10.1378/chest.98.5.1169) Copyright © 1990 The American College of Chest Physicians Terms and Conditions

Figure 2 Comparison of observed left ventricular mass with corresponding predicted normals (left), and of observed left ventricular cardiac output with predicted normals (right). The individual calculations for each patient are superimposed on the two standard deviation range of the predicted normal values for black control subjects. CHEST 1990 98, 1169-1174DOI: (10.1378/chest.98.5.1169) Copyright © 1990 The American College of Chest Physicians Terms and Conditions

Figure 3 Discriminant function analysis of echo dimension data showing statistical separation of normal black subjects (solid lines) and SCA patients (hatched lines). Left vertical axis refers to the number of cases in the frequency histogram, right vertical axis refers to the occurrence rate (percent) represented by the density function curves of 99 normal black subjects and 64 SCA patients. The horizontal axis refers to the Ydv (discriminant function) derived from the regression equation shown. CHEST 1990 98, 1169-1174DOI: (10.1378/chest.98.5.1169) Copyright © 1990 The American College of Chest Physicians Terms and Conditions

Figure 4 Discriminant values (Ydv) for echo dimension parameters plotted as a function of hemoglobin concentration (g%) (left), and as a function of percent S-hemoglobin (right). The regression equations, r values, and p values describing the correlations are shown. CHEST 1990 98, 1169-1174DOI: (10.1378/chest.98.5.1169) Copyright © 1990 The American College of Chest Physicians Terms and Conditions