Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage Guofen Gao 1 ;Nan Zhang 1 ;Yue-Qi Wang 1 ;Qiong Wu 1 ;Peng Yu 1 ;Zhen-Hua.

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Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage Guofen Gao 1 ;Nan Zhang 1 ;Yue-Qi Wang 1 ;Qiong Wu 1 ;Peng Yu 1 ;Zhen-Hua Shi 1 ;Xiang-Lin Duan 1 ;Bao-Lu Zhao 1 ;Wen-Shuang Wu 2 ;Chang Yan-Zhong 1 ; 1 Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, 050024, China ; 2 The 3rd Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, China ; Figure 5. FtMt overexpression attenuated the H 2 O 2 -induced increase of 55 Fe uptake and decrease of 55 Fe release Detailed determinations were described in #cod#x0201C;Materials and methods#cod#x0201D;. A 55 Fe uptake levels were shown as iron concentrations. Data represent means #cod#x000B1; SD; n=3 #cod#x0002A;, P #cod#x0003C;0.05, and #cod#x0002A;#cod#x0002A;, P #cod#x0003C; 0.01 vs. the untreated cells of same genotype; #, p #cod#x0003C; 0.05 vs. the H 2 O 2 -treated vector controls. B 55 Fe release levels were the percentages of iron in supernatant of cell culture against total iron sum of supernatant and cell lysate. Data represent means#cod#x000B1;SD; n=3 #cod#x0002A;#cod#x0002A;, P #cod#x0003C; 0.01 vs. the untreated cells of same genotype; ##, p #cod#x0003C; 0.01 vs. the H 2 O 2 -treated vector controls. Aging and Disease,null,8(4),458-470. Doi:10.14336/AD.2016.1108