Protein Synthesis and Protein Folding

Remember proteins? What are their monomers? Amino Acids – 20 to choose from Where are they synthesized in the cell? Ribosomes (poke your ribs!) What are some functions of proteins? Antibodies, Enzymes, Muscle fibers, growth, storage

Amino Acids

How do the amino acids know their order? DNA (***common genetic code!!!) codes for proteins DNA uses sequences of 3 bases called codons to tell the ribosome what amino acid comes next DNA – its your instructions!

Proteins and their function In order for proteins to be able to function they must be folded correctly (we say have the correct conformation) 4 levels of protein folding

Levels of Protein folding Primary – a strand of amino acids

Levels of Protein folding Secondary – amino acid chain doubles back on itself linked by H bonds Alpha (α) helix or Beta (β) pleated sheet

Levels of Protein folding Tertiary - α helix and βsheets fold onto themselves to make a 3D structure. This is the final structure of some proteins

Level of protein folding Quaternary – several tertiary proteins bonded together Working form of most proteins