From: Neurokinin-1 Receptor Antagonists Inhibit the Recruitment of Opioid-containing Leukocytes and Impair Peripheral Antinociception Anesthes. 2007;107(6):1009-1017.

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From: Neurokinin-1 Receptor Antagonists Inhibit the Recruitment of Opioid-containing Leukocytes and Impair Peripheral Antinociception Anesthes. 2007;107(6):1009-1017. doi:10.1097/01.anes.0000291454.90754.de Figure Legend: Fig. 3. Expression of substance P and neurokinin-1 (NK1) receptors in the inflamed hind paw. ( A ) Substance P content was measured in subcutaneous paw tissue 0–48 h after complete Freund adjuvant injection (CFA) by enzyme-linked immunosorbent assay (* P < 0.05, F = 7.6, analysis of variance, Student-Newman-Keuls method vs. 0 h CFA; n = 6/group). Data are presented as mean ± SEM. ( B ) NK1receptor expression ( red ) in the inflamed paw was demonstrated by fluorescent immunohistochemistry 24 h after CFA injection. Arrows point to NK1receptor immunoreactive endothelial cells, and arrowhead points to neurons (magnification 20×). In the inset , NK1receptor expression is shown on infiltrating cells (nuclei stained in blue , magnification 40×). Representative sections are shown. ( C ) NK1receptor expression on CD45+cells in the paw was measured by flow cytometry 24 h after CFA injection ( gray histogram = unstained control; dotted line = isotype control antibody; thick black line = anti-NK1receptor antibody). To exclude nonhematopoietic cells and cell debris, cells were pregated on CD45+leukocytes (data not shown). A representative histogram is shown. ( D ) To verify expression of NK1receptor on endothelial cells, inflamed paw tissue was analyzed by fluorescent immunohistochemistry for NK1receptor ( red ) and intercellular adhesion molecule 1 ( green ) 24 h after CFA injection. Coexpression of both markers is shown in yellow (magnification 20×). Date of download: 12/22/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.