From: Neurokinin-1 Receptor Antagonists Inhibit the Recruitment of Opioid-containing Leukocytes and Impair Peripheral Antinociception Anesthes. 2007;107(6):1009-1017.

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From: Neurokinin-1 Receptor Antagonists Inhibit the Recruitment of Opioid-containing Leukocytes and Impair Peripheral Antinociception Anesthes. 2007;107(6):1009-1017. doi:10.1097/01.anes.0000291454.90754.de Figure Legend: Fig. 4. Peripheral neurokinin-1 receptor blockade did not alter the expression of intercellular adhesion molecule 1 and neurokinin-1 receptors on endothelial cells at the site of inflammation. Rats (n = 5/group) were treated with complete Freund adjuvant for 24 h and with either neurokinin-1 receptor antagonist SR140333 (10 mg/kg intraperitoneal every 12 h;  C  and  F  ) or solvent only (  B  and  E  ). Noninflamed tissue was obtained from control animals without complete Freund adjuvant injection (  A  and  D  ). Tissue was analyzed by fluorescent immunohistochemistry for neurokinin-1 receptor (  red  ;  A  –  C  ) and intercellular adhesion molecule 1 (  green  ;  D  –  F  ) (magnification 20×). Representative sections are shown.  Date of download: 12/22/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.

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