Date of download: 12/22/2017 Copyright © ASME. All rights reserved. From: Development of a Simple Miniature Thermochemical Ablation Device Suitable for Tumor Ablation Research in Rodent Models J. Med. Devices. 2013;8(1):014501-014501-3. doi:10.1115/1.4025187 Figure Legend: Device (no delivery needle attached) with blunt needle tips extending just beyond terminus of Luer lock fitting. Inner portion of cap has been filled with cyanoacrylate glue to eliminate dead space and tips extend slightly to occupy space within the receiving (delivery) needle hub.

Date of download: 12/22/2017 Copyright © ASME. All rights reserved. From: Development of a Simple Miniature Thermochemical Ablation Device Suitable for Tumor Ablation Research in Rodent Models J. Med. Devices. 2013;8(1):014501-014501-3. doi:10.1115/1.4025187 Figure Legend: Device assembled with delivery needle, two delivery syringes, and extension tubing attached. Each syringe would be loaded and device primed prior to connection to final delivery needle. Final needle can be connected immediately, or inserted into target tissue prior to connection depending on circumstances. A syringe pump may also be used for precise control over injection rates.

Date of download: 12/22/2017 Copyright © ASME. All rights reserved. From: Development of a Simple Miniature Thermochemical Ablation Device Suitable for Tumor Ablation Research in Rodent Models J. Med. Devices. 2013;8(1):014501-014501-3. doi:10.1115/1.4025187 Figure Legend: Temperature data obtained using a thermocouple thermometer from injections of 0.25 mL each of 11M HCl and NaOH. Arrowhead in each case indicates time point for injection, which was performed after a brief period to establish the baseline temperature. Temperature increases of approximately 25 °C were noted within seconds after initiating each injection.

Date of download: 12/22/2017 Copyright © ASME. All rights reserved. From: Development of a Simple Miniature Thermochemical Ablation Device Suitable for Tumor Ablation Research in Rodent Models J. Med. Devices. 2013;8(1):014501-014501-3. doi:10.1115/1.4025187 Figure Legend: Gross photos of lesions created injecting 0.25 mL, 11M HCl simultaneously with 0.25 mL, 11M NaOH. Pale, tan coagulation zones are clearly visible measuring from 1–1.5 cm in diameter. Product of the reaction in tissues is NaCl.