Ductal carcinoma in situ (DCIS) Ductal carcinoma in situ (DCIS). A, The ducts are expanded by a proliferation of cells that “obey” each other's boundaries (i.e., do not overlap). This image illustrates low-grade DCIS. B, The ducts are expanded by a proliferation of cells; however, there is central necrosis. Comedo necrosis indicates high-grade DCIS. Hematoxylin and eosin, A, 100×; B, 40×. Source: Chapter 17. Pathology of the Male and Female Reproductive Tract and Breast, Pathology: The Big Picture Citation: Kemp WL, Burns DK, Brown TG. Pathology: The Big Picture; 2008 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/kemp1/kemp1_c017f025b.png&sec=41572599&BookID=499&ChapterSecID=41568300&imagename= Accessed: December 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved