Chapter 11 RES 219 Pharmacology

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Presentation transcript:

Chapter 11 RES 219 Pharmacology Corticosteroids Chapter 11 RES 219 Pharmacology

Corticosteroids Clinical indications What is a corticosteroid? HPA – Hypothalamic Pituitary Adrenal axis Diurnal rhythm HPA/adrenal suppression

Airway inflammation What causes inflammation? Terms: Immune system Antigens Immunoglobulins (IgE) Mast cells Histamine Bronchospasm Inflammation

Corticosteroids Mechanism of action Prevent “airway remodeling”

Aerosolized Corticosteroid Agents beclomethasone (QVAR) fluticasone (Flovent/Arnuity) budesonide (Pulmicort) ciclesonide (Alvesco) flunisolide (Aerospan) mometasone (Asmanex)

Combination (Steroid/LABA) Advair (fluticasone/salmeterol) Symbicort (budesonide/formoterol) Dulera (mometasone/formoterol) Breo (fluticasone/vilanterol)

Systemic steroids Prednisone Prednisolone Methylprednisolone (Solu-Medrol)

Adverse Effects of Corticosteroids Aerosol vs systemic Inhaled (local/topical) effects Systemic effects