Key structural elements of p53 DNA binding

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Key structural elements of p53 DNA binding Key structural elements of p53 DNA binding. Based on the crystal structure in Cho et al.295 L, LH, and LSH indicate loop, loop-helix, and loop-sheet-helix, respectively. Residues are indicated in single letter code and DNA contacts are indicated by arrows. For simplicity, only one strand is shown with arrows pointing to bases indicating a base contact and arrows pointing between bases indicating contacts to sugar or phosphate groups. (Modified with permission from Vogelstein and Kinzler.481 ) Source: Familial Cancer Syndromes, III. Defects in Gatekeepers, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: http://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch48fg19.png&sec=62668413&BookID=971&ChapterSecID=62632418&imagename= Accessed: December 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved