Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells Katherine E. Zychowski, Bethany Sanchez,

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Presentation transcript:

Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells Katherine E. Zychowski, Bethany Sanchez, Rodrigo P. Pedrosa, Geraldo Lorenzi-Filho, Luciano F. Drager, Vsevolod Y. Polotsky, Matthew J. Campen Atherosclerosis Volume 254, Pages 59-66 (November 2016) DOI: 10.1016/j.atherosclerosis.2016.09.017 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Experimental design. Twenty-three patients were divided into three groups: Healthy controls (n = 7), untreated (n = 8), and CPAP-treated (n = 8). OSA control or CPAP-treated patients were monitored before and after 3 months after treatment, and further subdivided into the following groups: pre-Untreated, post-Untreated, pre-CPAP, and post-CPAP. Atherosclerosis 2016 254, 59-66DOI: (10.1016/j.atherosclerosis.2016.09.017) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Baseline differences in endothelial cell inflammatory responses to serum from healthy and OSA subjects. Transcriptional responses of adhesion molecules (A–C: VCAM1, ICAM1, SELP) and cytokines (D–F: IL8, CCL5, CXCL12) are shown. Asterisks (*) indicate significant difference from control by an unpaired Mann-Whitney test (p < 0.05). Atherosclerosis 2016 254, 59-66DOI: (10.1016/j.atherosclerosis.2016.09.017) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Normalized endothelial cell transcriptional responses to serum from before and after 3 months of CPAP or OSA control. Data were normalized by individual subject baseline data to examine trends over the 3-month period. Significant treatment-related effects were noted by a repeated measures two-way ANOVA for ICAM1 and CCL5 mRNA (*p < 0.05). All other markers exhibited consistent, but non-significant trends. Atherosclerosis 2016 254, 59-66DOI: (10.1016/j.atherosclerosis.2016.09.017) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Leukocyte adhesion assay reveals significant loss in overall adhesion following CPAP compared to no therapy. (A) Mean recordings of endothelial monolayer resistance upon addition of monocytic THP-1 cells for all OSA subjects before treatment (black), after observation without treatment (red) or after CPAP therapy (blue). (B) By examining the net adhesion index for each subject before and after no treatment or CPAP therapy, we see trends for a reduction in cellular adhesion associated with the CPAP therapy (in 5/7 subjects) with minimal change in untreated subjects (1/7). Analysis by two-way ANOVA reveals a significant interaction between treatment groups and time (p = 0.019). Atherosclerosis 2016 254, 59-66DOI: (10.1016/j.atherosclerosis.2016.09.017) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions