Date of download: 12/22/2017 Copyright © ASME. All rights reserved. From: Computational Biomechanics of Human Red Blood Cells in Hematological Disorders J Biomech Eng. 2017;139(2):021008-021008-13. doi:10.1115/1.4035120 Figure Legend: Sickle cells in shear flow: (a) Successive snapshots of SS-RBCs in shear flow. Labels I, II, and III correspond to a deformable SS2 cell, rigid SS3 cell, and ISC, respectively. The arrow indicates the flow direction; (b-c) Instantaneous contact area and velocity for sickle RBC in shear flow conditions. (Reproduced from Ref. [95]).