From: Risk Factors for Prostate Cancer

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From: Risk Factors for Prostate Cancer Ann Intern Med. 1993;118(10):793-803. doi:10.7326/0003-4819-118-10-199305150-00007 Figure Legend: Age-adjusted death rates due to prostate cancer per 100 000 population.[7](From Boring and colleagues .). Date of download: 12/22/2017 Copyright © American College of Physicians. All rights reserved.

From: Risk Factors for Prostate Cancer Ann Intern Med. 1993;118(10):793-803. doi:10.7326/0003-4819-118-10-199305150-00007 Figure Legend: Comparison of the age-specific prevalence of prostate cancer in the United States and Japan.Top panel.Bottom panel.[1]Histologic prostate cancer. Clinical prostate cancer. (From Carter and colleagues .). Date of download: 12/22/2017 Copyright © American College of Physicians. All rights reserved.

From: Risk Factors for Prostate Cancer Ann Intern Med. 1993;118(10):793-803. doi:10.7326/0003-4819-118-10-199305150-00007 Figure Legend: Prostate cancer incidence rates for the years 1973 to 1990.Rates are shown for the tricounty metropolitan Detroit area as measured by the Surveillance, Epidemiology, and End Results (SEER) program. Rates are per 100000, are age-adjusted to the 1970 U.S. standard population, and are representative of new cancer cases diagnosed in a given year. Date of download: 12/22/2017 Copyright © American College of Physicians. All rights reserved.

From: Risk Factors for Prostate Cancer Ann Intern Med. 1993;118(10):793-803. doi:10.7326/0003-4819-118-10-199305150-00007 Figure Legend: Incidence rates by age and race for invasive prostate cancer.Rates are shown for metropolitan Detroit tricounty residents in 1989 as reported by the SEER data base. Rates are per 100000 and are age adjusted to the 1970 U.S. standard population. Date of download: 12/22/2017 Copyright © American College of Physicians. All rights reserved.

From: Risk Factors for Prostate Cancer Ann Intern Med. 1993;118(10):793-803. doi:10.7326/0003-4819-118-10-199305150-00007 Figure Legend: The positive correlation between breast and prostate cancer by country.[131]The incidence of both breast and prostate cancer is higher in more developed countries. These data suggest that environmental influences may be important in the promotion of these diseases (see text). (From Rose and colleagues .). Date of download: 12/22/2017 Copyright © American College of Physicians. All rights reserved.

From: Risk Factors for Prostate Cancer Ann Intern Med. 1993;118(10):793-803. doi:10.7326/0003-4819-118-10-199305150-00007 Figure Legend: The positive correlation between the mortality rate for prostate cancer and animal fat consumption by country.[131]These data suggest that high fat intake may be related to the risk for developing prostate cancer (see text). (From Rose and colleagues .). Date of download: 12/22/2017 Copyright © American College of Physicians. All rights reserved.

From: Risk Factors for Prostate Cancer Ann Intern Med. 1993;118(10):793-803. doi:10.7326/0003-4819-118-10-199305150-00007 Figure Legend: Potential sites of intervention for prostate cancer treatment and prevention.[13]A better understanding of the interplay of multiple hormones as well as other factors with the prostate will allow the potential design of new therapeutic strategies to intervene in the process of prostate carcinogenesis. Epidemiologic studies provide important clues in understanding the factors important in the development of prostate cancer. (Adapted from Coffey and Pienta ). ACTH = adrenocorticotropin releasing hormone; CNS = central nervous system; CRH= corticotropin releasing hormone; DHT = dihydrotestosterone; FSH = follicle stimulating hormone; FSH-RH = follicle stimulating hormone releasing hormone; LH = luteinizing hormone; LH-RH = luteinizing hormone releasing hormone; S = seminiferous; T = testosterone. Date of download: 12/22/2017 Copyright © American College of Physicians. All rights reserved.