Negative feedback inhibition of gastric emptying by enterogastrones

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Presentation transcript:

Negative feedback inhibition of gastric emptying by enterogastrones Negative feedback inhibition of gastric emptying by enterogastrones. The duodenum senses acidity, osmolarity, distension, and nutrient composition of the luminal contents to gauge the rate of gastric emptying. An increase in these variables stimulates the release of the hormones shown, resulting in feedback inhibition of gastric motility and secretion. This mechanism ensures that the rate of gastric emptying is not excessive. CCK, cholecystokinin; GIP, glucose-dependent insulinotropic polypeptide; VIP, vasoactive intestinal polypeptide. Source: Gastrointestinal Physiology, Medical Physiology: The Big Picture Citation: Kibble JD, Halsey CR. Medical Physiology: The Big Picture; 2015 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1291/p9780071485678-ch007_f012.png&sec=75577466&BookID=1291&ChapterSecID=75577353&imagename= Accessed: December 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved