David D. Yuh, MD, Kimberly L. Gandy, MD, Bruce A

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Perinatal induction of immunotolerance to cardiac and pulmonary allografts David D. Yuh, MD, Kimberly L. Gandy, MD, Bruce A. Reitz, MD, Grant Hoyt, Robert C. Robbins, MD The Journal of Thoracic and Cardiovascular Surgery Volume 114, Issue 1, Pages 64-75 (July 1997) DOI: 10.1016/S0022-5223(97)70118-1 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Tolerance to donor-strain (ACI) skin graft. Photograph displays an ACI skin graft on a tolerant Lewis recipient after 8 postoperative weeks. Note the pigmented phenotype of the hair produced from the viable ACI skin graft. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Histologic analysis of ACI cardiac allografts in nontolerant and tolerant Lewis recipients. Note the extensive perivascular and interstitial mononuclear cell infiltrates in an ACI cardiac allograft rejected by a Lewis recipient on postoperative day 7 (top). No histologic evidence of rejection was detected in ACI grafts sampled for biopsy 150 days after transplantation in tolerant Lewis rats (bottom). (Hematoxylin and eosin stain; original magnification ×100.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Histologic analysis of ACI cardiac allografts in nontolerant and tolerant Lewis recipients. Note the extensive perivascular and interstitial mononuclear cell infiltrates in an ACI cardiac allograft rejected by a Lewis recipient on postoperative day 7 (top). No histologic evidence of rejection was detected in ACI grafts sampled for biopsy 150 days after transplantation in tolerant Lewis rats (bottom). (Hematoxylin and eosin stain; original magnification ×100.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Chest radiographs of nontolerant (left) and tolerant (right) lung allograft recipients. The left lung field (reversed projection) is opacified in the nontolerant recipient, indicating rejection by postoperative day 7, compared with the nearly clear corresponding field in the tolerant animal 100 days after transplantation. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Histologic analysis of ACI lung allografts in nontolerant and tolerant Lewis recipients. Note the extensive perivascular mononuclear cell infiltrates extending into the adjacent alveolar septa in an ACI lung allograft rejected by a Lewis recipient on postoperative day 7 (top). No histologic evidence of rejection was detected in ACI grafts sampled for biopsy 100 days after transplantation in tolerant Lewis rats (bottom). (Hematoxylin and eosin stain; original magnification ×100.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Histologic analysis of ACI lung allografts in nontolerant and tolerant Lewis recipients. Note the extensive perivascular mononuclear cell infiltrates extending into the adjacent alveolar septa in an ACI lung allograft rejected by a Lewis recipient on postoperative day 7 (top). No histologic evidence of rejection was detected in ACI grafts sampled for biopsy 100 days after transplantation in tolerant Lewis rats (bottom). (Hematoxylin and eosin stain; original magnification ×100.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Representative flow cytometric plots of splenocyte populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the small subset of splenocytes expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Representative flow cytometric plots of splenocyte populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the small subset of splenocytes expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Representative flow cytometric plots of splenocyte populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the small subset of splenocytes expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Representative flow cytometric plots of splenocyte populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the small subset of splenocytes expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Representative flow cytometric plots of bone marrow populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the large subset of marrow cells expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Representative flow cytometric plots of bone marrow populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the large subset of marrow cells expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Representative flow cytometric plots of bone marrow populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the large subset of marrow cells expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Representative flow cytometric plots of bone marrow populations obtained from an adult naive recipient (Lewis), donor-strain positive control (ACI), and Lewis recipients inoculated with ACI fetal liver cells in utero (tolerant and nontolerant). Note the large subset of marrow cells expressing the donor phenotype in the tolerant rat. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 64-75DOI: (10.1016/S0022-5223(97)70118-1) Copyright © 1997 Mosby, Inc. Terms and Conditions