Figure 4. (A) A schematic representation from constructs that include modifications in Flag-TDP-12xQ/N. TDP-12xQ/N F4/L (F147, 149, 229, 231/L); TDP-12xQ/N.

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Figure 4. (A) A schematic representation from constructs that include modifications in Flag-TDP-12xQ/N. TDP-12xQ/N F4/L (F147, 149, 229, 231/L); TDP-12xQ/N ▵RRM1/2 (deleted RMM1 and RMM2); TDP-12xQ/N ▵RRM1/2, ▵N (deleted RMM1, RMM2 and N-terminal portion); TDP-12xQ/N ▵RRM1/2, ▵C (deleted RMM1, RMM2 and C-terminal portion). In (B) is reported an RT-PCR indicating the splicing pattern of endogenous POLDIP3/SKAR gene (exon 3) after the induction or not of Flag-TDP-12xQ/N or its corresponding mutant proteins. (C) A western blot performed with an anti-SKAR antibody using proteins extracted from the same samples used in (B) The red boxes enclose the splicing and protein expression pattern of the mutant that does not induce loss of function. From: TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain Hum Mol Genet. 2014;24(1):9-20. doi:10.1093/hmg/ddu415 Hum Mol Genet | © The Author 2014. Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com 1