Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World.

Slides:

Advertisements

Similar presentations

Successful Treatment for Chronic Hepatitis C-Autoimmune Hepatitis Overlap Syndrome due to Daclatasvir and Asunaprevir Case Rep Gastroenterol 2017;11:305–311.

Advertisements

Treatment of Primary and Metastatic Multifocal Mucosal Melanoma of the Oral Cavity with Imatinib - DOI: / Fig. 1. Multiple, partially confluent,

Routine Monitoring of Sodium and Phosphorus Removal in Peritoneal Dialysis (PD) Patients Treated with Continuous Ambulatory PD (CAPD), Automated PD (APD)

Impact of Intravenous P2Y12-Receptor Inhibition with Cangrelor in Patients Presenting with Acute Coronary Syndrome and Cardiogenic Shock – a.

Incomplete Annular Pancreas with Ectopic Opening of the Pancreatic and Bile Ducts into the Pyloric Ring: First Report of a Rare Anomaly Case Rep Gastroenterol.

Case Rep Nephrol Dial 2016;6:128– DOI: / © 2016 The Author(s)

Maintenance Hemodialysis Using Native Arteriovenous Fistula in a Patient with Severe Generalized Recessive Dystrophic Epidermolysis Bullosa Case Rep Nephrol.

Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized.

Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case Biomed Hub 2017;2: DOI: / © 2017 The Author(s) Published.

Case Rep Oncol 2017;10:361– DOI: /

Cerebrovasc Dis Extra 2017;7:62–71 - DOI: /

Deferasirox Decreases Liver Iron Concentration in Iron-Overloaded Patients with Myelodysplastic Syndromes, Aplastic Anemia and Other Rare Anemias Acta.

Pre-Interventional Kynurenine Predicts Medium-Term Outcome after Contrast Media Exposure Due to Coronary Angiography Kidney Blood Press Res 2017;42:244–256.

Body Mass Index in Different Dementia Disorders: Results from the Swedish Dementia Quality Registry (SveDem) Dement Geriatr Cogn Disord Extra 2014;4:65-75.

Case Rep Oncol 2017;10:462– DOI: /

Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach

Factors Associated with Blood Pressure Variability Based on Ambulatory Blood Pressure Monitoring in Subjects with Hypertension in China Kidney Blood Press.

Brain Perfusion in Corticobasal Syndrome with Progressive Aphasia

Reactive Eccrine Syringofibroadenoma Associated with Neuropathy, Venous Stasis, and Diabetic Foot Ulcer Case Rep Dermatol 2016;8:124–129 - DOI: /

Application of Laser Phoresis in Complicated Postmenopausal Osteoporosis Integr Med Int 2016;3: DOI: / Fig. 1. Zones of laser phoresis:

Effects of Glycyrrhizin in a Mouse Model of Lung Adenocarcinoma

The Effect of Retraining on Treatment Success, Quality of Life, and Metabolic Parameters in Patients with Type 1 Diabetes Using an Insulin Pump Med Princ.

Detection of Renal Hypoxia in Lupus Nephritis Using Blood Oxygen Level-Dependent MR Imaging: A Multiple Correspondence Analysis Kidney Blood Press Res.

Quantitative Renal Echogenicity as a Tool for Diagnosis of Advanced Chronic Kidney Disease in Patients with Glomerulopathies and no Liver Disease Kidney.

The Clinical Significance of Uric Acid and Complement Activation in the Progression of IgA Nephropathy Kidney Blood Press Res 2016;41: DOI: /

Fractional Excretion of Uric Acid as a Predictor for Saline Responsiveness in Long-Term Kidney Transplant Patients Kidney Blood Press Res 2012;35:627–633.

Effect of Salt Intake on Serum Glucagon-Like Peptide-1 Levels in Normotensive Salt-Sensitive Subjects Kidney Blood Press Res 2017;42:728–737 - DOI: /

A Patient with Supraclavicular Lymphadenopathy and Anterior Mediastinal Mass Presenting as a Rare Case of Composite Lymphoma: A Case Report and Literature.

Comparison between Early-Onset and Late-Onset Alzheimer's Disease Patients with Amnestic Presentation: CSF and 18F-FDG PET Study Dement Geriatr Cogn Disord.

Trends in Gene Expression Profiling for Prostate Cancer Risk Assessment: A Systematic Review Biomed Hub 2017;2: DOI: / © 2017 The.

Maximizing the Benefit-Cost Ratio of Anthracyclines in Metastatic Breast Cancer: Case Report of a Patient with a Complete Response to High-Dose Doxorubicin.

Recurrence of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in Appropriately Immunosuppressed Renal Transplant Patients: A Discussion of Two.

Use of a Toric Intraocular Lens and a Limbal-Relaxing Incision for the Management of Astigmatism in Combined Glaucoma and Cataract Surgery Case Rep Ophthalmol.

Disease Progression Modeling to Evaluate the Effects of Enzyme Replacement Therapy on Kidney Function in Adult Patients with the Classic Phenotype of Fabry.

Metastatic Castration-Resistant Prostate Cancer: Two Case Reports of Dramatic Response with Abiraterone Acetate in Patients Heavily Pretreated with Chemotherapy.

Tumors Presenting as Multiple Cranial Nerve Palsies

Case Rep Gastroenterol 2016;10:338– DOI: /

Significance of Urine Diagnostic Tests After Renal Transplantation

Plasma Cell Leukemia Presenting as a Chest Wall Mass: A Case Report

Case Rep Gastroenterol 2017;11:312– DOI: /

Dynamics of Glucose Metabolism After Kidney Transplantation

Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series.

Cerebrovasc Dis Extra 2017;7:51–61 - DOI: /

T-Cell Lymphoma in a Patient with Neurofibromatosis Type 1 and AIDS

Near Complete Response in a Patient with Classical Hodgkin Lymphoma Treated with Brentuximab Vedotin Concurrent with Radiation Therapy - DOI: /

Pancreatic Acinar Cell Carcinoma

Determinants of Overweight and Obesity in Lung Transplant Recipients

Ten-Year Survival of a Patient Treated with Stereotactic Gamma Knife Radiosurgery for Brain Metastases from Colon Cancer with Ovarian and Lymph Node Metastases:

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised,

Pulmonary Hypertension Is Associated with Mortality and Cardiovascular Events in Chronic Kidney Disease Patients Am J Nephrol 2017;45: DOI: /

Elotuzumab, Lenalidomide, and Low-Dose Dexamethasone in Relapsed/Refractory Myeloma Slideset on: Lonial S, Vij R, Harousseau JL, et al. Elotuzumab in combination.

Verrucous Squamous Cell Cancer in the Esophagus: An Obscure Diagnosis

The Broken Health Information Technology Innovation Pipeline: A Perspective from the NODE Health Consortium - DOI: / Fig. 1. The Food and.

An Uncommon Presentation of a Metachronous Testicular Primary Nonseminoma and Seminoma Separated by Two Decades and a Testicular Cancer Literature Review.

ZNF750 Expression Is a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma Oncology - DOI: / Fig. 1. The immunohistochemical.

Posterior Wall Collapse in High Myopia following Cataract Surgery

Successful Treatment with S-1 and Oxaliplatin Combination Therapy in an Elderly Patient with Metastatic Colorectal Cancer Initially Presenting with Membranous.

Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer Med Princ Pract - DOI: /

Intra-Arterial Mechanical Thrombectomy: An Effective Treatment for Ischemic Stroke Caused by Endocarditis Case Rep Neurol 2016;8:229–233 - DOI: /

Single-Agent Carboplatin for a Rare Case of Pilomyxoid Astrocytoma of the Spinal Cord in an Adult with Neurofibromatosis Type 1 Case Rep Oncol 2016;9:568–573.

Long-Term Follow-Up Case of Multiple Retinal Arterial Macroaneurysms Developing Branch Retinal Vein Occlusion following Ruptured Macroaneurysm Case Rep.

Exploring Factors Associated with Depression and Anxiety among Hospitalized Patients with Type 2 Diabetes Mellitus Med Princ Pract - DOI: /

Adjuvant Dose-Dense Chemotherapy in Breast Cancer: Standard of Care in High-Risk Patients Breast Care 2016;11: DOI: / Fig. 1. Strategies.

Long-Term Disease Control by Pomalidomide-/Dexamethasone-Based Therapy in a Patient with Advanced Multiple Myeloma: A Case Report and Review of the Literature.

Intrathoracic Hernia after Total Gastrectomy

Unilateral Posterior Polymorphous Corneal Dystrophy Presented as Anisometropic Astigmatism: 3 Case Reports Case Rep Ophthalmol 2017;8:250–258 - DOI: /

Kidney Blood Press Res 2014;39: DOI: /

Response to Carfilzomib Therapy

Oncogenic Human Papillomavirus: Application of CRISPR/Cas9 Therapeutic Strategies for Cervical Cancer Cell Physiol Biochem 2017;44:2455– DOI: /

Digital Medicine: A Primer on Measurement

Presentation transcript:

Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138:55-60 - DOI:10.1159/000477792 Fig. 1. The schedule for dose adjustment. Lenalidomide (Len) was started on a minimum dose and gradually increased to the highest dose during days 1-21. © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138:55-60 - DOI:10.1159/000477792 Fig. 2.a The median TTP was 11.8 months (range 8.4-21.9). b The median OS was 39.2 months (range 26.6 to not determined). Lenalidomide was started on a minimum dose and gradually increased to the highest dose during days 1-14. © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138:55-60 - DOI:10.1159/000477792 Fig. 3. Correlation between cumulative doses and best response. The median cumulative dose was 1,097.5 mg (range 80-9,870). The correlation coefficient between cumulative dose and best response was 0.134 (p = 0.324). CR, complete response; VGPR, very good partial response; PR, partial response; SD, stable disease; PD, progressive disease. © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138:55-60 - DOI:10.1159/000477792 Table 1. Patient characteristics © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138:55-60 - DOI:10.1159/000477792 Table 2. Comparison of starting and continued doses © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138:55-60 - DOI:10.1159/000477792 Table 3. Reasons for reduction © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138:55-60 - DOI:10.1159/000477792 Table 4. Response rate © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0