Maintaining distinct domains within tissues

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Presentation transcript:

Maintaining distinct domains within tissues Dahmann et al., 2011

Drosophila imaginal discs Grewal, 2013

Compartments in the wing disc Tabata, 2001

Ectopic Hh clone results in anterior duplication Tabata, 2001

Clonal analysis revealed compartments McNeill, 2000

Hh clones resulting in compartment invasion McNeill, 2000

Maintaining distinct compartments by signaling gradient Monier et al., 2011

Alternatives to maintaining compartment boundaries Monier et al., 2011

Alternatives to maintaining compartment boundaries Monier et al., 2011

References Dahmann C, Oates AC, Brand M. Boundary formation and maintenance in tissue development. Nat Rev Genet. 2011 Jan;12(1):43-55. Grewal, S. Instant Messaging. The Scientist 2013 27:3 McNeill H Sticking together and sorting things out: adhesion as a force in development. Nat Rev Genet. 2000 Nov;1(2):100-8. Monier B, Pélissier-Monier A, Sanson B. Establishment and maintenance of compartmental boundaries: role of contractile actomyosin barriers. Cell Mol Life Sci. 2011 Jun;68(11):1897-910. Tetsuya Tabata (2001) Genetics of morphogen gradients. Nature Reviews Genetics 2, 620-630