Day Date Reading Topic T 9/3 pp.216-231 (Ch. 6) C. elegans, model systems, and molecular genetics Watch three Audio/Video handouts: 1A), 1B), and 1C Th 9/5 Ch. 1 An introduction to developmental biology T 9/10 QUIZ 1 (covers A/V Handouts 1A, 1B, and 1C) More introduction Watch two Audio/Video handouts: Review of transcription regulation, Parts 1 and 2 Th 9/12 Ch. 3 Vertebrate life cycles T 9/17 QUIZ 2 (covers A/V Handouts 2A and 2B) Vertebrate axes and germ layers Th 9/19 CH. 4 Vertebrate axial patterning T 9/24 More vertebrate body plan Th 9/26 Ch. 5 Early patterning of vertebrate nervous systems T 10/1 exam date changed Th 10/3 Ch. 2 Molecular development of Drosophila T 10/8 EXAM 1 Chapters 1, 3, 4, and pp216-231 Lectures and Handouts Th 10/10 Ch. 7 Plant development On Thursday, 10/10, please bring a copy of the primary research article you have selected (or more than one if you haven’t decided) plus your notes on the article.

The Hox gene family are examples of homeotic genes. Homeotic genes are genes that when mutant cause a change in the spatial position of structures (change in address). wild-type fruit fly antennapedia mutant Box 4A

The Hox gene family are examples of homeotic genes. The Hox gene products give the positional address along the Anterior-Posterior (A/P) axis in all animals. Box 4A

The Hox gene family are examples of homeotic genes. The Hox genes encode a family of paralogous proteins that are sequence-specific DNA-binding transcription factors.

The Hox gene family are examples of homeotic genes. The Hox proteins bind to response elements in the promoter DNA of target genes. The DNA-binding domain of the protein is called the homeodomain:

The Hox gene family are examples of homeotic genes. Hox proteins work in a combinatorial manner to determine A/P axis address. Fig. 4.9

Figs. 4.27, 4.28

Fig. 5.3

Fig. 5.18

Fig. 5.20

Fig. 5.29

%ig. 5.31

Chapter 2: Drosophila embryogenesis

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Genes to focus on during Drosophila embryogenesis Bicoid Hunchback Even-skipped Engrailed Antennapedia Hedgehog Wingless Gurken Toll Dorsal Decapentaplegic Short gastrulation

BIO305 Exam #1 Distribution   98 * A 97 96 95 ** A 94 93 92 * A 91 90 * A 89 *** A/A- 88 A/A- 87 86 B+ 85 ** B+ 84 * B+ 83 * B+/B 82 ** B+/B 81 B 80 * 79 * B 78 77 76 75 74 * B- 73 ** B- 72 *** B-/C+ 71 * B-/C+   65 * C- 58 * D 47 * F