E-mail: iheanyi.okonko@uniport.edu.ng; +2348035380891 Low Level of Pre-Vaccination Measles Antibody among Infants Receiving Measles Immunization In Ilorin,

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E-mail: iheanyi.okonko@uniport.edu.ng; +2348035380891 Low Level of Pre-Vaccination Measles Antibody among Infants Receiving Measles Immunization In Ilorin, Kwara State, Nigeria 1Fowotade A, 2Okonko, I.O, 3Nwabuisi C, 3Fadeyi A, 1Bakare, RA and 4Adu FD 1Department of Medical Microbiology & Parasitology, University College Hospital, Ibadan, Nigeria *2Medical Microbiology Unit, Department of Microbiology, University of Port Harcourt, Port Harcourt, Nigeria E-mail: iheanyi.okonko@uniport.edu.ng; +2348035380891 INTRODUCTION RESULTS Table 3: Impact of Previous Measles on Pre-Vaccination Measles Virus Antibody Titer Of all the 400 infants screened for pre-vaccination measles antibodies, 29(7.2%) had protective antibody titer while 156 (39.0%) had low titer since ≥40 HI titer is the study threshold of protection against measles while 215(53.8%) had no detectable measles antibody titer (<1:10). Thirty-one (8.0%) of the infants had measles prior to vaccination. Previous history of measles was significant associated (P=0.0005, X2 = 34.507) with the level of pre-vaccination measles virus antibody. There was no significant difference (p=0.723) in the level of measles virus antibody among the exclusively breastfed infants and those that were not exclusively breast fed. Age (p=0.839) and sex (p=0.1999) were not significantly associated with the level of measles virus antibody. The distribution of this antibody levels appeared stable with no significant difference between age groups, sex and breast feeding pattern. Only the previous history of measles showed statistical association with measles virus antibody proportion. Measles infection occurs worldwide but it is epidemic in developing countries where severe morbidity and high mortality are associated with underlying malnutrition, poverty, and indiscriminate vaccination services. History Total (%) Pre-vaccination measles virus antibody titer (%)   <1:10 1:10 1:20 >1:40 (%) No 369(92.3) 214(99.5) 92(96.8) 56(91.8) 7(13.8) Yes 31(7.7) 1(0.5) 3(3.2) 5(8.2) 22(75.9) Total 400(100.0) 215(53.7) 95(23.7) 61(15.3) 29(7.3) Table 4: Impact of Exclusive Breastfeeding on Pre-Vaccination Antibody Titer OBJECTIVE This study was designed to assess the low levels of pre-vaccination measles antibody among infants receiving measles immunization in Ilorin, Kwara State, Nigeria. Age (months) Total (%) No. Exclusive breastfeeding No. Mixed feeding PRE-VACCINATION MEASLES VIRUS ANTIBODY LEVELS (%) <1:10 1:10 1:20 >1:40 E M 9 236(59.0) 122(51.7) 114(48.3) 71(30.1) 59(25.0) 34(14.4) 25(10.6) 14(5.9) 18(7.6) 3(1.3) 12(5.1) 10 84(21.0) 42(50.0) 20(23.8) 24(28.6) 7(8.3) 12(14.3) 9(10.7) 3(3.6) 6(7.1) 11 56(14.0) 20(35.7) 36(64.3) 10(17.9) 17(30.4) 6(10.7) 8(14.3) 2(3.6) 9(16.1) 12 24(6.0) 5(20.8) 19(79.2) 1(4.2) 13(54.2) 2(8.3) 0(0.0) Total 400(100.0) 189(47.3) 211(52.7) 102(25.5) 113(28.3) 49(12.3) 46(11.5) 26(6.5) 35(8.8) 12(3.0) 17(4.3) METHOD Pre-vaccination blood samples were obtained from 400 infants brought to the EPI Clinic of the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Blood samples were collected by finger puncture onto ROPACO (Rochester, USA) rectangular filter paper measuring 7 cm by 10 cm. Other information like name, age, sex, date of vaccination was also recorded on the filter paper. The filter papers were dried at ambient temperature and stored in plastic bags at -200C until ready for serum extraction. Specimens were analyzed for measles antibody using Hemagglutination Inhibition technique. Data generated were subjected to Chi square statistical test to establish association between categorical variables with dichotomous outcomes. CONCLUSION Table 1: Pre-Vaccination Measles Virus Antibody Titer According to the Age of Infants In conclusion, a larger proportion (53.8%) of the children had no detectable anti-measles virus antibody while 39.0% had low (non-protective) titer; these put both groups at risk of developing measles given the endemic nature of Nigeria. Therefore, re-evaluation of 9 months as the age for measles vaccination in Nigeria vis-à-vis 92.8% with <40 HI titer is highly recommended. Age (months) No. (%) Pre-vaccination Measles Virus Antibody titer (%) <1:10 1:10 1:20 >1:40 9 236(59.0) 130(55.1) 59(25.0) 32(13.6) 15(6.3) 10 84(21.0) 44(52.4) 19(22.6) 12(14.3) 9(10.7) 11 56(14.0) 27(48.2) 14(25.0) 11(19.6) 4(7.1) 12 24(6.0) 14(58.3) 3(12.5) 6(25.0) 1(4.2) Total 400(100.0) 215(53.7) 95(23.7) 61(15.3) 29(7.3) Table 2: Pre-Vaccination Measles Virus Antibody Titers According to the Sex of Infants REFERENCES Sex No. (%) Pre-Vaccination Measles Virus Antibody (%) <1:10 1:10 1:20 >1:40 Males 245(61.3) 133(54.3) 60(24.5) 37(15.1) 15(6.1) Females 155(38.7) 82(52.9) 35(22.6) 24(15.5) 14(9.0) Total 400(100.0) 215(53.7) 95(23.7) 61(15.3) 29(7.3) 1. Ogundiji OT, Okonko IO, Adu FD. Determination Of Measles Haemagglutination Inhibiting Antibody Levels Among School Children In Ibadan, Nigeria. Journal of Immunoassay and Immunochemistry, 2013; 34:208-217 2. Okonko IO, Onoja BA, Adedeji AO, et al. The Role of Vaccines in Elimination and Global Eradication of Measles- A Review of Literature. African Journal of Pharmacy and Pharmacology, 2009; 3(9): 413-425