Reproductive Physiology Lecture 1 Hypothalamic-Pituitary-Gonadal axis

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Reproductive Physiology Lecture 1 Hypothalamic-Pituitary-Gonadal axis Dr.Mohammed Alotaibi Assistant Professor of Physiology College of Medicine Department of Physiology Email: mfalotaibi@ksu.edu.sa Tel: 0114672629

OBJECTIVES By the end of this lecture, you should be able to: Describe the regulation of hypothalamic secretion of GnRH and its physiological role on LH & FSH secretion from the anterior pituitary gland. Explain the mechanism by which LH & FSH regulate sexual function in males and females. Describe the negative and positive feedback mechanisms in the hypothalamic-pituitary-gonadal axis (HPG axis) and their importance in the control of reproductive function

The anterior pituitary secretes six hormones:   1. Adrenocorticotropic hormone (ACTH) 2. Thyroid-stimulating hormone (TSH) 3. Growth hormone (GH) 4. Prolactin (PRL) 5. Follicle-stimulating hormone (FSH) 6. Luteinizing hormone (LH) Secretion of AP hormone is controlled by “releasing hormones” formed in the hypothalamus and transported to the AP gland by the hypothalamic-hypophyseal portal system.

Hypothalamic → Pituitary→ Gonadal axis lactotropes Thyrotropes Somatotropes Corticotropes Gonadotropes

Hypothalamus HPG axis

Control of male sexual functions by hormones from the hypothalamus and anterior pituitary gland GnRH is secreted intermittently for few minutes every 1 to 3 hrs. – The secretion of LH by the anterior pituitary is also cyclical following the pulsatile release of GnRH. Conversely, FSH secretion increases and decreases only slightly with each fluctuation of GnRH secretion Testosterone Spermatogenesis

GnRH is secreted in pulses lasting 5 to 25 minutes every 1 to 2 hrs Regulation of the female monthly rhythm, interplay between the ovarian and hypothalamic-pituitary hormones Intermittent, pulsatile secretion of GnRH by the hypothalamus stimulates pulsatile release of LH & FSH from the AP. GnRH is secreted in pulses lasting 5 to 25 minutes every 1 to 2 hrs

Negative feedback effects of estrogen and progesterone in decreasing both LH and FSH secretion

Female Ovarian Follicle

The End Thank You

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