Harry Hochheiser Assistant Professor

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Presentation transcript:

Biomedical Knowledge Navigation: Interactive tools for clinical and research insight Harry Hochheiser Assistant Professor Department of Biomedical Informatics Intelligent Systems Program University of Pittsburgh Center for Causal Discovery (www.ccd.pitt.edu) Biomedical Informatics Training Program

The data interpretation challenge Clinicians and translational researchers are swamped with data Lab measurements, meds, clinical notes, imaging data in EMRs Genomics, microbiome, expression profiles, phenotypes.. Experts need tools that Get them closer to the data Facilitate exploration and hypothesis generation Visual analytics to support knowledge work as an ongoing process Goal: Develop innovative tools that reduce the gap between data and insight Approach Qualitative investigation of problem domains and user needs and challenges Iterative prototyping and refining of ideas Mixed-methods (qualitative and quantitative) evaluations

Clinical and Translational Applications Navigation and exploration tools for data repositories Developmental Biology, 355(2), 2011. Hochheiser, et al. Collaborator identification in research social networks J. Medical Internet Research 16(11).e244,2014. Borromeo, et al. Exploration of genotype-phenotype relationships Mammalian Genome 2015. Haendel, et al. Interactive review of natural language processing results from clinical notes TextVis 2015, Trivedi, et al.

Ongoing Support The Monarch Initiative: Linking diseases to model organism resources NIH OD: R24OD011883, R24OD011883-03S1 Interactive Search and Review of Clinical Records with Multilayered Semantic Annotation NLM: R01LM 010964 Sarcoidosis and A1AT Genomics & Informatics Center NHLBI: U01HL112707, U01 HL112707-02A1S1 Addressing gaps in clinically useful evidence on drug-drug interactions NLM: R01LM011838 Cancer Deep Phenotype Extraction from Electronic Medical Records NCI: U24CA184407 Center for Causal Modeling and Discovery of Biomedical Knowledge from Big Data NHGRI: U54HG008540 Quantifying Electronic Medical Records Usability to Improve Clinical Workflow AHRQ: R01HS021290 Human Genomics Analysis Interface For FaceBase 2. NIDCR: U01DE024425