MECHE UPDATE 30/03/2011.

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Presentation transcript:

MECHE UPDATE 30/03/2011

RECRUITMENT MALES FEMALES Participants (n) 100 114 Caucasian (%) 91 97 Age (yrs) 32.0 ± 9.7 31.4 ± 11.3 BMI (kg.m2) 26.2 ± 4.0 24.4 ± 5.0 Waist (cm) 88 ± 12 79 ± 13 Normal weight (%) 42 70 Overweight (%) 47 23 Obese (%) 11 7 56% 44%

PAIRED TEST MEAL PROTOCOLS MALES FEMALES OLTT– OLTT 28 35 OGTT– OLTT 33 38 OGTT– OGTT 63 71 66 200 pairs

ADIPOSE TISSUE SAMPLES MALES FEMALES Paired samples 4 5 Single samples 8 No. candidates refusing biopsy 6 4% 6% 5% 15% Cohort eligible for biopsy 10% gave a sample

ASSOCIATED INFORMATION No. 204 Dexa scans, Metabolic rate, Bod pod, Fitness, Strength Analysis underway 205 Self report dietary habits (FFQ) Analysis complete 204 Self report physical activity (EPAQ) Analysis to be completed April 2011

Metabolic syndrome biochemistry SAMPLE ANALYSIS Metabolic syndrome biochemistry Daytona autoanalyser Basic biochemical analysis underway Cholesterol, HDL, TGs, Glu, NEFAs, APOs Forecasted completion date: Early June

Protein profiling & Proteomics Evidence investigator platform Metabolic array almost complete Insulin-Leptin-Resistin-PAI1-Cpeptide Cytokine array work underway Il’s-VEGF-TNFa-Ifg-MCP1 To be completed Mid April Adhesion molecules array yet to start ICAM-VCAM-E/P/L-selectin

Metabolomics analysis NMR - 214 fasting urine samples 190 postprandial samples Total 404 urine samples GCMS - 91 fasting urine samples

Transcriptomic analysis Work on 4 sub-cohorts underway 1 (n=10, lean, 18-30yrs) PBMC gene expression, Single gene and pathway analysis, ELISAs 2 & 3 (n=8, 18-30/>30kg.m2, 30-60yrs) Arrays in progress 4 (n=9, adipose tissue biopsy group) RNA isolated, Arrays in progress Results forecasted: Summer

Genotyping . Sample collection complete and all samples (n=212) sent to TCD biobank Awaiting DNA extraction?? Item 4 : Agenda

CLINICAL VARIABLES DATABASE SAMPLE ANALYSIS DATABASE STATUS OF DATABASES CLINICAL VARIABLES DATABASE SAMPLE ANALYSIS DATABASE SPORTS DATABASE FFQ DATABASE

STATUS OF DATABASES METABOLOMICS PROTEOMICS TRANSCRIPTOMICS CLINICAL BIOCHEMISTRY FFQ METABOLOMICS SPORTS PHYSICAL ACTIVITY PROTEOMICS TRANSCRIPTOMICS