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Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Swine model of severe injury and hemorrhagic shock. 3:1 ISCS indicates isotonic sodium chloride solution at a volume 3 times the controlled hemorrhage volume. Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Clotting factor activity and coagulation assays comparing the postreconstitution value with the prelyophilization value. Values are expressed as means. AT indicates antithrombin III; INR, international normalized ratio; and PTT, partial thromboplastin time. Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Total blood loss. Values are expressed as mean (SD). FFP indicates fresh frozen plasma; LP, lyophilized plasma; and PRBCs, packed red blood cells. *LP-PRBC group less than FFP group (447 mL vs 564 mL, P = .03). †LP-PRBC group less than LP group (447 mL vs 630 mL, P = .004). ‡LP-PRBC group less than FFP-PRBC group (447 mL vs 609 mL, P = .006). Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Heart rate. Values are expressed as mean (SD). FFP indicates fresh frozen plasma; LP, lyophilized plasma; and PRBCs, packed red blood cells. P values were not significant at all time points after initiation of resuscitation. Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Mean arterial pressure (MAP). Values are expressed as mean (SD). FFP indicates fresh frozen plasma; LP, lyophilized plasma; and PRBCs, packed red blood cells. *LP group higher than FFP group. †LP-PRBC group higher than FFP group. ‡FFP-PRBC group higher than FFP group. §LP-PRBC group higher than LP group. (For all of these comparisons, P < .05.) Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Plasma lactate levels. Values are expressed as mean (SD). FFP indicates fresh frozen plasma; LP, lyophilized plasma; and PRBCs, packed red blood cells. Plasma lactate levels were similar between all groups at all time points after initiation of resuscitation. To convert lactate to milligrams per deciliter, divide by 0.111. Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Prothrombin time (PT). Values are expressed as mean (SD). FFP indicates fresh frozen plasma; LP, lyophilized plasma; and PRBCs, packed red blood cells. Prothrombin time was similar between groups at all time points after initiation of resuscitation. Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Partial thromboplastin time (PTT). Values are expressed as mean (SD). FFP indicates fresh frozen plasma; LP, lyophilized plasma; and PRBCs, packed red blood cells. *FFP group lower than LP-PRBC group. †FFP group lower than FFP-PRBC group. ‡LP group lower than LP-PRBC group. §LP group lower than FFP-PRBC group. (For all comparisons, P < .05.) Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Lyophilized Plasma for Resuscitation in a Swine Model of Severe Injury Arch Surg. 2009;144(9):829-834. doi:10.1001/archsurg.2009.154 Figure Legend: Interleukin 6 (IL-6). Values are expressed as medians with interquartile ranges. FFP indicates fresh frozen plasma; LP, lyophilized plasma; and PRBCs, packed red blood cells. *LP group less than FFP-PRBC group (P = .02). †LP-PRBC group less than FFP-PRBC group (P = .009). ‡LP group less than FFP group (P = .049). Date of download: 12/24/2017 Copyright © 2009 American Medical Association. All rights reserved.