Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor Tommi.

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Presentation transcript:

Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor Tommi E Vaskivuo, M.D., Kristiina Aittomäki, M.D., Ph.D., Mikko Anttonen, M.D., Aimo Ruokonen, M.D., Ph.D., Riitta Herva, M.D., Ph.D., Yoshio Osawa, M.D., Markku Heikinheimo, M.D., Ph.D., Ilpo Huhtaniemi, M.D., Ph.D., Juha S Tapanainen, M.D., Ph.D. Fertility and Sterility Volume 78, Issue 1, Pages 108-113 (July 2002) DOI: 10.1016/S0015-0282(02)03148-5

FIGURE 1 Aromatase cytochrome P450 and GATA-4 expression, and apoptosis in ovarian tissue from individuals with the Ala189Val FSH receptor gene mutation and from normal adult and fetal ovarian tissue. (A), In ovaries from women with the FSH receptor mutation, only negligible aromatase immunostaining was observed. (B), In normal adult ovaries strong aromatase immunostaining was found in growing follicles. (C), Only very weak aromatase staining was observed in fetal ovaries. (D), Women with the FSH receptor mutation showed only negligible ovarian GATA-4 expression. (E), In normal adult ovaries, GATA-4 immunostaining was observed in granulosa cells of growing follicles. (F), In normal fetal ovaries, GATA-4 staining was observed in follicular granulosa cells as well as in stromal cells. (G), Ovarian apoptosis was not detected in women with the FSH receptor mutation. (H), In normal adult ovarian tissue, apoptosis was localized to the follicular granulosa cells. (I), In normal fetal ovarian tissue, apoptosis was mainly localized to the oocytes, although apoptotic granulosa cells were also observed. Scale bars = 5 μm. Vaskivuo. Gonadal steroidal response in FSH receptor mutation. Fertil Steril 2002. Fertility and Sterility 2002 78, 108-113DOI: (10.1016/S0015-0282(02)03148-5)