CD36 Polymorphism Is Associated with Protection from Cerebral Malaria

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CD36 Polymorphism Is Associated with Protection from Cerebral Malaria Kazuya Omi, Jun Ohashi, Jintana Patarapotikul, Hathairad Hananantachai, Izumi Naka, Sornchai Looareesuwan, Katsushi Tokunaga The American Journal of Human Genetics Volume 72, Issue 2, Pages 364-374 (February 2003) DOI: 10.1086/346091 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Graphical representation of identified polymorphisms and the TG repeat in intron 3, in relation to the exon-intron structure of the human CD36 gene. The American Journal of Human Genetics 2003 72, 364-374DOI: (10.1086/346091) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Pattern of LD in CD36. Pairwise LD between polymorphisms, as measured on the basis of D′, is represented. The graphs are adjusted for physical distance. Regions of high and low degrees of LD are shown in red and blue, respectively. a, Pairwise D′ in Thai patients with cerebral malaria (upward triangle) and mild malaria (downward triangle). b, Pairwise D′ in ED (upward triangle) and AD (downward triangle) Americans. The American Journal of Human Genetics 2003 72, 364-374DOI: (10.1086/346091) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 3 The variant CD36 transcript produced by exon skipping. a, Schematic representation of alternative splicing of CD36, causing the variant CD36 transcript. b, Expression of the variant CD36 transcript that lacks exons 4 and 5 was examined by RT-PCR with cDNAs from human PBMC. Numbers above each lane refer to the genotypes of in3(TG)n; for example, “16/16” is homozygous for in3(TG)16. In each case, PCR products of the expected sizes were observed for the variant CD36 transcript that lacks exons 4 and 5 (top), the CD36 transcript from exons 2 and 3 (middle), and GAPDH (bottom). The PCR products were separated on 10% polyacrylamide gel and were stained by Syber Gold (Molecular Probes). The American Journal of Human Genetics 2003 72, 364-374DOI: (10.1086/346091) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 4 Overview of the seven most common haplotypes estimated in 203 patients with mild malaria and 108 patients with cerebral malaria. The green boxes represent major alleles, and the yellow boxes represent minor alleles at biallelic sites. M = patients with mild malaria; C = patients with cerebral malaria. The American Journal of Human Genetics 2003 72, 364-374DOI: (10.1086/346091) Copyright © 2003 The American Society of Human Genetics Terms and Conditions