Partial regimen replacement with aripiprazole reduces serum prolactin in patients with a long history of schizophrenia: A case series Keiko Naono-Nagatomo,

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Presentation transcript:

Partial regimen replacement with aripiprazole reduces serum prolactin in patients with a long history of schizophrenia: A case series Keiko Naono-Nagatomo, MD, PhD, Hisao Naono, MD, Hiroshi Abe, PhD, Ryuichiro Takeda, MD, PhD, Hideki Funahashi, MD, PhD, Daisuke Uchimura, MD, PhD, Yasushi Ishida, MD, PhD Asian Journal of Psychiatry Volume 25, Pages 36-41 (February 2017) DOI: 10.1016/j.ajp.2016.10.005 Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 1 Number of patients included in the analysis. Asian Journal of Psychiatry 2017 25, 36-41DOI: (10.1016/j.ajp.2016.10.005) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 2 Change in serum prolactin, body weight, and blood glucose over time. Serum prolactin level was decreased significantly at month 6 relative to month 0 (*p<0.05, Bonferroni). Body weight and blood glucose did not significantly differ over time. Asian Journal of Psychiatry 2017 25, 36-41DOI: (10.1016/j.ajp.2016.10.005) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 3 Correlation between changes in serum prolactin relative to baseline at month 0. A significant negative correlation was observed (Spearman’s r=−0.99, p<0.01). Asian Journal of Psychiatry 2017 25, 36-41DOI: (10.1016/j.ajp.2016.10.005) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 4 GAF evaluation scores. A one-way ANOVA and subsequent multiple comparison tests revealed significant score improvements at months 1, 3, and 6 relative to month 0 (*p<0.05, Bonferroni). Asian Journal of Psychiatry 2017 25, 36-41DOI: (10.1016/j.ajp.2016.10.005) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 5 CGI-I evaluation scores. A one-way ANOVA and subsequent multiple comparison tests revealed significant score improvements at months 1, 3, and 6 relative to month 0 (*p<0.05, Bonferroni). Asian Journal of Psychiatry 2017 25, 36-41DOI: (10.1016/j.ajp.2016.10.005) Copyright © 2016 Elsevier B.V. Terms and Conditions