Metabolomics Research Core

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Presentation transcript:

Metabolomics Research Core GENERAL Review literature to determine relevancy, level of innovation, and likelihood of success in proposed area of research Prepare grants and manuscripts Review metadata associated with samples in biorepository for appropriate samples selection Provide guidance on sample collection, storage, analytical methods, standards, environmental measures TYPES OF ASSAYS Broad spectrum metabolomic via UPLC-Q-TOF-MS, 2D-GC-TOF-MS, and NMR GC-MS - organic acids, free fatty acids, and total fatty acids LC-MS/MS - acylcarnitines, acyl coenzymes, biogenic amines, lipids, phospholipids, and amino acids NMR and LC-MS/MS for metabolite identification ICP-MS for metals, minerals, and metallomics Experience with PM, VOCs, PFOS, OCs, OPPs, pyrethroids, non-persistent pollutants, phthalate monoesters and metabolites, flame retardants, and hydroxylated metabolites of PCBs and PBDEs. DATA ANALYSIS Statistical and mathematical tools (e.g., Umetrics, Spotfire, SAS), and GeneGo and expert biochemist interpretation METABOLITE STANDARDS SYNTHESIS Synthesis and characterization of mass and isotopic (13C, 15N, 14C) CONTACT Susan Sumner, ssumner@rti.org, PI of the Eastern Regional Comprehensive Metabolomics Research Core (ERCMRC) grant - has set aside $50K per year from the ERCMRC grant to form 5-10 collaborations with the CHHE faculty. CHHE faculty can apply to CHHE to receive seed funds to support metabolomics analysis. The ERCMRC calls for pilot study proposals (for up to $50K each) on Jan 15th, 2016. Get Ready!