Cognitive Function and Kidney Disease: Baseline Data From the Systolic Blood Pressure Intervention Trial (SPRINT)  Daniel E. Weiner, MD, MS, Sarah A. Gaussoin, MS, John Nord, MD, MS, Alexander P. Auchus, MD, Gordon J. Chelune, PhD, Michel Chonchol, MD, Laura Coker, PhD, William E. Haley, MD, Anthony A. Killeen, MD, PhD, Paul L. Kimmel, MD, Alan J. Lerner, MD, Suzanne Oparil, MD, Mohammad G. Saklayen, MBBS, Yelena M. Slinin, MD, MS, Clinton B. Wright, MD, MS, Jeff D. Williamson, MD, Manjula Kurella Tamura, MD, MPH  American Journal of Kidney Diseases  Volume 70, Issue 3, Pages 357-367 (September 2017) DOI: 10.1053/j.ajkd.2017.04.021 Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Associations of urine albumin-creatinine ratio (ACR; upper panel) and estimated glomerular filtration rate (eGFR; lower panel) with cognitive domains show nonlinear associations between either urine ACR or eGFR equations and cognitive performance, shown on the y-axis as the parameter estimate for the ACR or GFR subgroup for each domain. Reference is ACR < 10mg/g and eGFR of 75 to <90mL/min/1.73m2, respectively. In multivariable analyses adjusting for model 3 variables including eGFR for ACR models and ACR for eGFR models, P for trend for the association with global cognitive function is 0.03 and 0.02; for executive function, 0.002 and <0.001; for memory, 0.18 and 0.08; for attention/concentration, 0.04 and 0.3; and for language, 0.9 and 0.3, for ACR and GFR models, respectively. Lines are presented for only global cognitive function. American Journal of Kidney Diseases 2017 70, 357-367DOI: (10.1053/j.ajkd.2017.04.021) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions